(3R)-3-Amino-3-(2-thienyl)propanoic acid

Basic Information

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CAS Number

73495-10-0

Molecular Formula

C7H9NO2S

Molecular Weight

171.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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N[C@H](CC(=O)O)c1cccs1

InChI

InChI=1S/C7H9NO2S/c8-5(4-7(9)10)6-2-1-3-11-6/h1-3,5H,4,8H2,(H,9,10)/t5-/m1/s1

InChIKey

GYAYLYLPTPXESE-RXMQYKEDSA-N

LogP

1.2226

Topological Polar Surface Area

63.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

151

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

(R)-3-Amino-3-(thiophen-2-yl)propanoic acid
(R)-3-Amino-3-(2-thienyl)propionic acid
(R)-3-Amino-3-(2-thienyl)-propionic acid
3-Amino-3-(2-thienyl)propanoic acid
(3r)-3-amino-3-(2-thienyl)propanoic acid
(3R)-3-amino-3-thiophen-2-ylpropanoic acid
GYAYLYLPTPXESE-RXMQYKEDSA-N
AB17732
(R)-beta-Amino-2-thiophenepropionic acid
R-3-Amino-3-(2-thienyl)-propionic acid
ST2402640
TL80073931
( R)-3-Amino

MDL Number

MFCD04113649

FAQ

What are the physical and chemical properties of (3R)-3-Amino-3-(2-thienyl)propanoic acid (CAS: 73495-10-0)?

(3R)-3-Amino-3-(2-thienyl)propanoic acid is a white crystalline solid with a molecular weight of approximately 191.21 g/mol. It is slightly soluble in water and has low solubility in organic solvents. This compound is reactive, particularly towards nucleophiles and can participate in condensation reactions. It forms salts with common inorganic acids and bases.

How is (3R)-3-Amino-3-(2-thienyl)propanoic acid (CAS: 73495-10-0) typically synthesized?

(3R)-3-Amino-3-(2-thienyl)propanoic acid is typically synthesized via the nucleophilic substitution of 2-thiophenecarbonyl chloride with ammonia in the presence of a base like triethylamine. The reaction is carried out under anhydrous conditions to avoid side reactions. The yield is usually around 70-80% with good regioselectivity towards the (3R) configuration.

What industries use (3R)-3-Amino-3-(2-thienyl)propanoic acid (CAS: 73495-10-0)?

(3R)-3-Amino-3-(2-thienyl)propanoic acid is used in the pharmaceutical industry as a precursor for the synthesis of bioactive molecules and in the polymer industry for the development of novel materials with specific properties. It also has applications in the sensor and semiconductor industries due to its thienyl moiety.

What precautions should be taken when handling (3R)-3-Amino-3-(2-thienyl)propanoic acid (CAS: 73495-10-0)?

When handling (3R)-3-Amino-3-(2-thienyl)propanoic acid, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood due to its volatility. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the SDS for detailed safety information.