(3R)-3-Amino-3-(2-thienyl)propanoic acid(CAS: 73495-10-0)

(3R)-3-Amino-3-(2-thienyl)propanoic acid is a white crystalline solid with a molecular weight of approximately 191.21 g/mol. It is slightly soluble in water and has low solubility in organic solvents. This compound is reactive, particularly towards nucleophiles and can participate in condensation reactions. It forms salts with common inorganic acids and bases.

(3R)-3-Amino-3-(2-thienyl)propanoic acid is typically synthesized via the nucleophilic substitution of 2-thiophenecarbonyl chloride with ammonia in the presence of a base like triethylamine. The reaction is carried out under anhydrous conditions to avoid side reactions. The yield is usually around 70-80% with good regioselectivity towards the (3R) configuration.

(3R)-3-Amino-3-(2-thienyl)propanoic acid is used in the pharmaceutical industry as a precursor for the synthesis of bioactive molecules and in the polymer industry for the development of novel materials with specific properties. It also has applications in the sensor and semiconductor industries due to its thienyl moiety.

When handling (3R)-3-Amino-3-(2-thienyl)propanoic acid, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood due to its volatility. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the SDS for detailed safety information.