Compound Q&A
How is (3R)-3-Amino-3-(2-thienyl)propanoic acid (CAS: 73495-10-0) typically synthesized?
Answer
(3R)-3-Amino-3-(2-thienyl)propanoic acid is typically synthesized via the nucleophilic substitution of 2-thiophenecarbonyl chloride with ammonia in the presence of a base like triethylamine. The reaction is carried out under anhydrous conditions to avoid side reactions. The yield is usually around 70-80% with good regioselectivity towards the (3R) configuration.
About
CAS No
73495-10-0
English Name
(3R)-3-Amino-3-(2-thienyl)propanoic acid
Molecular Formula
C7H9NO2S
Molecular Weight
171.22 g/mol
SMILES
N[C@H](CC(=O)O)c1cccs1
InChIKey
GYAYLYLPTPXESE-RXMQYKEDSA-N
Last Updated: 2025-11-07 12:11
