2-Chloro-5-(trifluoromethyl)-3-pyridinamine

Basic Information

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CAS Number

72587-18-9

Molecular Formula

C6H4ClF3N2

Molecular Weight

196.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

95-100°C

Water Solubility

Slightly soluble in water.

SMILES

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C1=C(C=NC(=C1N)Cl)C(F)(F)F

InChI

InChI=1S/C6H4ClF3N2/c7-5-4(11)1-3(2-12-5)6(8,9)10/h1-2H,11H2

InChIKey

HABKYPVMMHBOIW-UHFFFAOYSA-N

LogP

2.3360000000000003

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

161

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Chloro-3-amino-5-(trifluoromethyl)pyridine
3-AMINO-2-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE
AM62443
2-Chloro-5-(trifluoromethyl)pyridin-3-amine
2-chloro-5-(trifluoromethyl)-3-pyridinamine
A866237
AC-28816
72587-18-9
DTXSID50512961
SY033498
3-amino-2-chloro-5-trifluoromethylpyridine
RB1098
SCHEMBL756227
FT-0681812
J-508795
AKOS006287521
CS-W019209
BCP31450
MFCD07375383
AS-18526
2-Chloro-5-(trifluoromethyl)-3-pyridinamine
3-Amino-2-chloro-5-(trifluoromethyl)pyridine
Indole-4-boronic acid
HABKYPVMMHBOIW-UHFFFAOYSA-N
FCH856041
TL8005070
AX8168808
AB0026447
ST240279

MDL Number

MFCD07375383

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-5-(trifluoromethyl)-3-pyridinamine (CAS: 72587-18-9)?

2-Chloro-5-(trifluoromethyl)-3-pyridinamine is a crystalline compound with a molecular weight of approximately 245.6 g/mol. It has a high solubility in organic solvents like DMSO and acetone but is poorly soluble in water. The compound shows moderate reactivity, particularly towards nucleophiles, and is stable under normal storage conditions.

How is 2-Chloro-5-(trifluoromethyl)-3-pyridinamine (CAS: 72587-18-9) typically synthesized?

2-Chloro-5-(trifluoromethyl)-3-pyridinamine is typically synthesized via a nucleophilic substitution reaction involving 5-chloro-3-pyridinamine and trifluoromethyl chloromethyl ether. The reaction is catalyzed by a Lewis acid such as aluminum chloride and proceeds with good selectivity and yield under anhydrous conditions.

What industries use 2-Chloro-5-(trifluoromethyl)-3-pyridinamine (CAS: 72587-18-9)?

2-Chloro-5-(trifluoromethyl)-3-pyridinamine finds application in the pharmaceutical industry as an intermediate in the synthesis of certain medicinals. It is also used in the polymer industry for developing advanced materials and in the sensor industry for its unique chemical reactivity.

What precautions should be taken when handling 2-Chloro-5-(trifluoromethyl)-3-pyridinamine (CAS: 72587-18-9)?

When handling 2-Chloro-5-(trifluoromethyl)-3-pyridinamine, protective equipment such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.