2-Chloro-5-(trifluoromethyl)-3-pyridinamine(CAS: 72587-18-9)

2-Chloro-5-(trifluoromethyl)-3-pyridinamine is a crystalline compound with a molecular weight of approximately 245.6 g/mol. It has a high solubility in organic solvents like DMSO and acetone but is poorly soluble in water. The compound shows moderate reactivity, particularly towards nucleophiles, and is stable under normal storage conditions.

2-Chloro-5-(trifluoromethyl)-3-pyridinamine is typically synthesized via a nucleophilic substitution reaction involving 5-chloro-3-pyridinamine and trifluoromethyl chloromethyl ether. The reaction is catalyzed by a Lewis acid such as aluminum chloride and proceeds with good selectivity and yield under anhydrous conditions.

2-Chloro-5-(trifluoromethyl)-3-pyridinamine finds application in the pharmaceutical industry as an intermediate in the synthesis of certain medicinals. It is also used in the polymer industry for developing advanced materials and in the sensor industry for its unique chemical reactivity.

When handling 2-Chloro-5-(trifluoromethyl)-3-pyridinamine, protective equipment such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.