4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride

Basic Information

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CAS Number

7232-21-5

Molecular Formula

C14H23Cl2N3O2

Molecular Weight

336.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

182-188°C

Boiling Point

418.7 °C at 760 mmHg

Flash Point

207 °C

Solubility

H2O: soluble

SMILES

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CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl

InChI

InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H

InChIKey

RVFUNJWWXKCWNS-UHFFFAOYSA-N

LogP

2.424200000000001

Topological Polar Surface Area

67.59 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

300

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

MLS002222202
4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide hydrochloride
Metozolv
7B1QZY5SWZ
EINECS 230-634-5
A923754
NCGC00094102-03
Metoclopramide monohydrochloride
7232-21-5
M 0763
EN300-18536337
Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride (9CI)
UNII-7B1QZY5SWZ
Q27267998
Primperan (tablet)
SMR000058471
NC00519
Metoclopramide (hydrochloride)
NS00093557
NCGC00261447-01
Rimetin
MLS001074186
METOCLOPRAMIDEHCL
CHEMBL1256771
MFCD00058011
HMS1568J19
EU-0100762
Metoclopramide hydrochloride
MLS000069667
Clopra

MDL Number

MFCD00058011

FAQ

What are the physical and chemical properties of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (CAS: 7232-21-5)?

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride is a crystalline compound with a molecular weight of approximately 413.88 g/mol. It has a solubility of about 14.7 mg/mL in water and is stable to hydrolysis in the absence of strong acids or bases. Reactivity is limited to nucleophilic substitution and electrophilic aromatic substitution. This compound is not flammable and has a low risk of reactivity under normal conditions.

How is 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (CAS: 7232-21-5) typically synthesized?

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride is typically synthesized via a multistep process involving the reaction of 5-chloro-2-methoxybenzoic acid with diethylamine, followed by the coupling of the resulting amide with 4-aminobenzamide. The overall reaction involves the use of coupling reagents such as HATU or EDC, and the use of a base like diisopropylethylamine. The yield and selectivity are typically high, with purification achieved through recrystallization from aqueous media.

What industries use 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (CAS: 7232-21-5)?

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties. Additionally, it may find applications in the polymer industry for specific functional polymers.

What precautions should be taken when handling 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (CAS: 7232-21-5)?

When handling 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.