4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride(CAS: 7232-21-5)

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride is a crystalline compound with a molecular weight of approximately 413.88 g/mol. It has a solubility of about 14.7 mg/mL in water and is stable to hydrolysis in the absence of strong acids or bases. Reactivity is limited to nucleophilic substitution and electrophilic aromatic substitution. This compound is not flammable and has a low risk of reactivity under normal conditions.

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride is typically synthesized via a multistep process involving the reaction of 5-chloro-2-methoxybenzoic acid with diethylamine, followed by the coupling of the resulting amide with 4-aminobenzamide. The overall reaction involves the use of coupling reagents such as HATU or EDC, and the use of a base like diisopropylethylamine. The yield and selectivity are typically high, with purification achieved through recrystallization from aqueous media.

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties. Additionally, it may find applications in the polymer industry for specific functional polymers.

When handling 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.