2-(4-Fluorophenyl)pyrrolidine

Basic Information

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CAS Number

72216-06-9

Molecular Formula

C10H12FN

Molecular Weight

165.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

Liquid

Boiling Point

235.5℃ at 760 mmHg

SMILES

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C1CC(NC1)C2=CC=C(C=C2)F

InChI

InChI=1S/C10H12FN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2

InChIKey

ZDCXMSDSTZZWAX-UHFFFAOYSA-N

LogP

2.2501999999999995

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

141

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Synonyms & References

English

2-(4-fluorophenyl)pyrrolidine, AldrichCPR
AKOS016341057
2-(4-Fluorophenyl)-pyrrolidine
FT-0601695
(RS)-2-(4-fluoro-phenyl)-pyrrolidine
EN300-26301
AR1040
Z221586518
MFCD02663411
A26406
FT-0656204
AM804282
CS-0001894
SCHEMBL169111
FT-0659814
AKOS000200861
J-505995
BB 0219906
Oprea1_475262
2-(4-fluoro-phenyl)-pyrrolidine
AC-450
SY008993
PYRROLIDINE, 2-(4-FLUOROPHENYL)-
PS-6897
72216-06-9
2-(4-Fluorophenyl)pyrrolidine
A820082
AB12040
DTXSID40397587
2-(4-Fluoro-phenyl)-pyrrolidine
Pyrrolidine, 2-(4-fluorophenyl)-

MDL Number

MFCD02663411

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-(4-Fluorophenyl)pyrrolidine (CAS: 72216-06-9)?

2-(4-Fluorophenyl)pyrrolidine is a colorless to white crystalline solid with a molecular weight of approximately 180.17 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and ethanol. This compound is known for its chemical stability and can be reactive towards acidic or basic conditions. It is often used in chemical synthesis due to its favorable reactivity and functional group diversity.

How is 2-(4-Fluorophenyl)pyrrolidine (CAS: 72216-06-9) typically synthesized?

2-(4-Fluorophenyl)pyrrolidine is typically synthesized via the condensation of 4-fluorophenylacetic acid with pyrrolidine. This reaction is often catalyzed by a strong base such as sodium hydride. The yield is usually around 70-80% with good selectivity for the desired pyrrolidine derivative. Other methods, such as direct reaction of 4-fluorophenylacetyl chloride with pyrrolidine, can also be used.

What industries use 2-(4-Fluorophenyl)pyrrolidine (CAS: 72216-06-9)?

2-(4-Fluorophenyl)pyrrolidine is commonly used in pharmaceuticals for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, this compound has potential applications in the production of sensors and semiconductors due to its unique chemical structure and reactivity.

What precautions should be taken when handling 2-(4-Fluorophenyl)pyrrolidine (CAS: 72216-06-9)?

When handling 2-(4-Fluorophenyl)pyrrolidine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from sources of heat and light. In case of a spill, it should be handled in a fume hood with appropriate containment to avoid inhalation or skin contact. For detailed safety information, refer to the Safety Data Sheet (SDS) for proper handling and disposal instructions.