2-(4-Fluorophenyl)pyrrolidine(CAS: 72216-06-9)

2-(4-Fluorophenyl)pyrrolidine is a colorless to white crystalline solid with a molecular weight of approximately 180.17 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and ethanol. This compound is known for its chemical stability and can be reactive towards acidic or basic conditions. It is often used in chemical synthesis due to its favorable reactivity and functional group diversity.

2-(4-Fluorophenyl)pyrrolidine is typically synthesized via the condensation of 4-fluorophenylacetic acid with pyrrolidine. This reaction is often catalyzed by a strong base such as sodium hydride. The yield is usually around 70-80% with good selectivity for the desired pyrrolidine derivative. Other methods, such as direct reaction of 4-fluorophenylacetyl chloride with pyrrolidine, can also be used.

2-(4-Fluorophenyl)pyrrolidine is commonly used in pharmaceuticals for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, this compound has potential applications in the production of sensors and semiconductors due to its unique chemical structure and reactivity.

When handling 2-(4-Fluorophenyl)pyrrolidine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from sources of heat and light. In case of a spill, it should be handled in a fume hood with appropriate containment to avoid inhalation or skin contact. For detailed safety information, refer to the Safety Data Sheet (SDS) for proper handling and disposal instructions.