2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol

Basic Information

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CAS Number

722-92-9

Molecular Formula

C9H7F6NO

Molecular Weight

259.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

147-152 °C

Boiling Point

292.9°C at 760 mmHg

SMILES

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C1=CC(=CC=C1C(C(F)(F)F)(C(F)(F)F)O)N

InChI

InChI=1S/C9H7F6NO/c10-8(11,12)7(17,9(13,14)15)5-1-3-6(16)4-2-5/h1-4,17H,16H2

InChIKey

TZEJXCIGVMTMDY-UHFFFAOYSA-N

LogP

2.581000000000001

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

252

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

4-Amino-a,a-bis(trifluoromethyl)benzenemethanol
SGLSVIUONDXTPO-UHFFFAOYSA-N
CS-W004983
4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)aniline
MLS000564290
4-(Hexafluoro-2-hydroxyisopropyl)aniline
SCHEMBL289673
2-Hydroxy-2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropane
MFCD00039258
4-(hexafluoro-2-hydroxy-2-propyl)aniline
GS-6686
2-(4-Aminophenyl)-1 pound not1 pound not1 pound not3 pound not3 pound not3-hexafluoropropan-2-ol
2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol, 96%
HMS1409F18
4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenylamine
2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol #
Benzenemethanol, 4-amino-.alpha.,.alpha.-bis(trifluoromethyl)-
2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)-ethyl]benzenamine
2-(4-Aminophenyl)hexafluoro-2-propanol
4-(hexafluoro-2-hydroxy-2-propyl)-aniline
AKOS001053137
SMR000151804
HMS2395B16
2-(4-Amino-phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
SY046978
EN300-02317
Z56922114
p-Amino-a,a-bis(trifluoromethyl)benzyl alcohol
2-(4-AMINOPHENYL)HEXAFLUOROPROPAN-2-OL
FT-0608578

MDL Number

MFCD00039258

Customs Code

2922199090

FAQ

What are the physical and chemical properties of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (CAS: 722-92-9)?

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol is a colorless liquid with a molecular weight of approximately 290.07 g/mol. It is moderately soluble in water but soluble in organic solvents. Chemically, it is reactive with bases and nucleophiles. It exists as a crystalline solid at room temperature but is typically used in liquid form due to its low boiling point and high vapor pressure.

How is 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (CAS: 722-92-9) typically synthesized?

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol is synthesized via a multistep process involving the reaction of 4-hydroxybenzaldehyde with hexafluoroacetone followed by reduction and amidation. Commonly, this involves catalytic reduction using palladium or rhodium catalysts under hydrogen atmosphere and subsequent amidation with an amine reagent. The overall yield of the product can be up to 85%. The reaction is selective and provides high purity products.

What industries use 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (CAS: 722-92-9)?

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol is used in the pharmaceutical industry for its reactivity and functional groups, aiding in drug discovery and synthesis. It is also utilized in polymer science for modifying materials and in sensor technology for its unique chemical properties. Additionally, it has applications in the semiconductor industry due to its chemical stability and low volatility.

What precautions should be taken when handling 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (CAS: 722-92-9)?

When handling 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be handled in a fume hood or well-ventilated area to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.