2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol(CAS: 722-92-9)

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol is a colorless liquid with a molecular weight of approximately 290.07 g/mol. It is moderately soluble in water but soluble in organic solvents. Chemically, it is reactive with bases and nucleophiles. It exists as a crystalline solid at room temperature but is typically used in liquid form due to its low boiling point and high vapor pressure.

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol is synthesized via a multistep process involving the reaction of 4-hydroxybenzaldehyde with hexafluoroacetone followed by reduction and amidation. Commonly, this involves catalytic reduction using palladium or rhodium catalysts under hydrogen atmosphere and subsequent amidation with an amine reagent. The overall yield of the product can be up to 85%. The reaction is selective and provides high purity products.

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol is used in the pharmaceutical industry for its reactivity and functional groups, aiding in drug discovery and synthesis. It is also utilized in polymer science for modifying materials and in sensor technology for its unique chemical properties. Additionally, it has applications in the semiconductor industry due to its chemical stability and low volatility.

When handling 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be handled in a fume hood or well-ventilated area to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.