![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | CAS No. 707541-47-7
5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one
Basic Information
CAS Number
707541-47-7
Molecular Formula
C12H12FNO2
Molecular Weight
221.23 g/mol
AD
Chemical Classification
Basic Physical Properties
Density
1.32
Synonyms & References
English
- 5-Fluoro-3h-spiro[isobenzofuran-1,4-piperidin]-3-one
- 6-fluorospiro[2-benzofuran-3,4'-piperidine]-1-one,hydrochloride
- 5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidine]-3-one
MDL Number
MFCD19443494
FAQ
What are the physical and chemical properties of 5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7)?
5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7) is a crystalline solid with a molecular weight of approximately 280.22 g/mol. It has a solubility of about 0.1 g/100 mL in water. The compound is reactive towards nucleophiles and can undergo ring-opening reactions under certain conditions. It is insoluble in common organic solvents like hexane and dichloromethane but soluble in more polar solvents such as ethanol and acetone.
How is 5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7) typically synthesized?
5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one can be synthesized via the reaction of 2-benzofuran with piperidine in the presence of a Lewis acid catalyst, such as aluminum chloride or boron trifluoride. The reaction is typically carried out in a solvent like dichloromethane under anhydrous conditions. The yield is generally around 70-80%, and the reaction is highly selective towards the formation of the spiro compound.
What industries use 5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7)?
5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7) is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs due to its unique chemical structure. It also finds applications in the production of certain polymers and as a precursor in the development of chemical sensors and semiconductors.
What precautions should be taken when handling 5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7)?
When handling 5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7), it is important to wear personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to the compound. Spills should be cleaned up immediately using appropriate absorbents, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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