5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one(CAS: 707541-47-7)

5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7) is a crystalline solid with a molecular weight of approximately 280.22 g/mol. It has a solubility of about 0.1 g/100 mL in water. The compound is reactive towards nucleophiles and can undergo ring-opening reactions under certain conditions. It is insoluble in common organic solvents like hexane and dichloromethane but soluble in more polar solvents such as ethanol and acetone.

5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one can be synthesized via the reaction of 2-benzofuran with piperidine in the presence of a Lewis acid catalyst, such as aluminum chloride or boron trifluoride. The reaction is typically carried out in a solvent like dichloromethane under anhydrous conditions. The yield is generally around 70-80%, and the reaction is highly selective towards the formation of the spiro compound.

5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7) is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs due to its unique chemical structure. It also finds applications in the production of certain polymers and as a precursor in the development of chemical sensors and semiconductors.

When handling 5-Fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 707541-47-7), it is important to wear personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to the compound. Spills should be cleaned up immediately using appropriate absorbents, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.