Difluoro Atorvastatin Acetonide tert-Butyl Ester | CAS No. 693793-87-2
Difluoro Atorvastatin Acetonide tert-Butyl Ester
Basic Information
CAS Number
693793-87-2
Molecular Formula
C40H46F2N2O5
Molecular Weight
672.81 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
NA
Boiling Point
677.4±55.0 °C at 760 mmHg
Density
1.2±0.1 g/cm3
Flash Point
363.5±31.5 °C
Vapor Pressure
0.0±2.1 mmHg at 25°C
Synonyms & References
English
- Difluoro Atorvastatin Acetonide tert-Butyl Ester
- Tert-butyl 2-[(4R,6R)-6-[2-[2,3-bis(4-fluorophenyl)-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]eth
- tert-butyl 2-((4R,6R)-6-(2-(2,3-bis(4-fluorophenyl)-5-isopropyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
FAQ
What are the physical and chemical properties of Difluoro Atorvastatin Acetonide tert-Butyl Ester (CAS: 693793-87-2)?
Difluoro Atorvastatin Acetonide tert-Butyl Ester is a crystalline compound with a molecular weight of approximately 452.27 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetone and dichloromethane. The compound is relatively stable under normal storage conditions but is sensitive to moisture and light. It is not highly reactive, but care should be taken to avoid contact with strong acids or bases due to potential hydrolysis.
How is Difluoro Atorvastatin Acetonide tert-Butyl Ester (CAS: 693793-87-2) typically synthesized?
Difluoro Atorvastatin Acetonide tert-Butyl Ester is synthesized through a multi-step process, starting from atorvastatin acetonide. The key steps involve protection of the double bond, introduction of fluorine atoms, and formation of the tert-butyl ester group. The process uses standard synthetic methods, including the use of Lewis acids as catalysts and selective fluorination reactions. The overall yield is moderate, around 50-60%, with good selectivity towards the desired product.
What industries use Difluoro Atorvastatin Acetonide tert-Butyl Ester (CAS: 693793-87-2)?
Difluoro Atorvastatin Acetonide tert-Butyl Ester is primarily used in the pharmaceutical industry for the development and production of atorvastatin, a cholesterol-lowering drug. It is also of interest in academic research for studying the effects of fluorinated compounds on biological systems. While not commonly used in other industries like polymers or semiconductors, it may have potential applications in advanced materials research.
What precautions should be taken when handling Difluoro Atorvastatin Acetonide tert-Butyl Ester (CAS: 693793-87-2)?
When handling Difluoro Atorvastatin Acetonide tert-Butyl Ester, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats to protect against skin and eye contact. The compound should be stored in a cool, dry place away from direct sunlight and moisture. In case of a spill, it should be handled carefully to avoid inhaling the dust or vapor. It is advisable to consult the Safety Data Sheet (SDS) for detailed handling and emergency response procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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