Difluoro Atorvastatin Acetonide tert-Butyl Ester(CAS: 693793-87-2)

Difluoro Atorvastatin Acetonide tert-Butyl Ester is a crystalline compound with a molecular weight of approximately 452.27 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetone and dichloromethane. The compound is relatively stable under normal storage conditions but is sensitive to moisture and light. It is not highly reactive, but care should be taken to avoid contact with strong acids or bases due to potential hydrolysis.

Difluoro Atorvastatin Acetonide tert-Butyl Ester is synthesized through a multi-step process, starting from atorvastatin acetonide. The key steps involve protection of the double bond, introduction of fluorine atoms, and formation of the tert-butyl ester group. The process uses standard synthetic methods, including the use of Lewis acids as catalysts and selective fluorination reactions. The overall yield is moderate, around 50-60%, with good selectivity towards the desired product.

Difluoro Atorvastatin Acetonide tert-Butyl Ester is primarily used in the pharmaceutical industry for the development and production of atorvastatin, a cholesterol-lowering drug. It is also of interest in academic research for studying the effects of fluorinated compounds on biological systems. While not commonly used in other industries like polymers or semiconductors, it may have potential applications in advanced materials research.

When handling Difluoro Atorvastatin Acetonide tert-Butyl Ester, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats to protect against skin and eye contact. The compound should be stored in a cool, dry place away from direct sunlight and moisture. In case of a spill, it should be handled carefully to avoid inhaling the dust or vapor. It is advisable to consult the Safety Data Sheet (SDS) for detailed handling and emergency response procedures.