Compound Q&A
How is Difluoro Atorvastatin Acetonide tert-Butyl Ester (CAS: 693793-87-2) typically synthesized?
Answer
Difluoro Atorvastatin Acetonide tert-Butyl Ester is synthesized through a multi-step process, starting from atorvastatin acetonide. The key steps involve protection of the double bond, introduction of fluorine atoms, and formation of the tert-butyl ester group. The process uses standard synthetic methods, including the use of Lewis acids as catalysts and selective fluorination reactions. The overall yield is moderate, around 50-60%, with good selectivity towards the desired product.
About
CAS No
693793-87-2
English Name
Difluoro Atorvastatin Acetonide tert-Butyl Ester
Molecular Formula
C40H46F2N2O5
Molecular Weight
672.81 g/mol
SMILES
CC(C)C1=C(C(=C(N1CCC2CC(OC(O2)(C)C)CC(=O)OC(C)(C)C)C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C(=O)NC5=CC=CC=C5
InChIKey
FXOZEZIWLMWZMX-UHFFFAOYSA-N
Last Updated: 2026-01-04 19:14