(1R,2S)-2-Aminocyclohexanol hydrochloride (1:1)

Basic Information

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CAS Number

6936-47-6

Molecular Formula

C6H14ClNO

Molecular Weight

151.63 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

186-190 °C

Boiling Point

201.1 ºCat 760 mmHg

Density

1.037

Flash Point

75.4 ºC

SMILES

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C1CCC(C(C1)N)O.Cl

InChI

InChI=1S/C6H13NO.ClH/c7-5-3-1-2-4-6(5)8;/h5-6,8H,1-4,7H2;1H/t5-,6+;/m0./s1

InChIKey

LKKCSUHCVGCGFA-RIHPBJNCSA-N

LogP

1.75090

Complexity

74.9

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

cis-2-Amino-cyclohexanol hydrochloride
Cis (1R,2S)-2-amino-cyclohexanol hydrochloride
AKOS015849279
LKKCSUHCVGCGFA-RIHPBJNCSA-N
cis-2-Aminocyclohexanol hydrochloride
(1R,2S)-2-AMINOCYCLOHEXANOL HCL
A51241
CS-W008152
MFCD00143981
(1R,2S)-2-Aminocyclohexanol, HCl
MFCD11618002
A847410
DS-4377
6936-47-6
190792-72-4
Cyclohexanol, 2-amino-, hydrochloride (1:1), (1R,2S)-
CIS-2-AMINOCYCLOHEXANOL HCL
AKOS015899612
cis,2-amino-cyclohexanol hydrochloride
EN300-119083
(1R,2S)-2-aminocyclohexan-1-ol;hydrochloride
A9175
(1R,2S)-cis-2-Aminocyclohexanol hydrochloride, >=97% (GC)
(1R,2S)-2-Aminocyclohexanolhydrochloride
(1R,2S)-2-aminocyclohexanol hydrochloride;S-2-amino-1,1,3-triphenylpropan-1-ol
SCHEMBL939033
cis-2-Aminocyclohexanol hydrochloride, AldrichCPR
Cyclohexanol, 2-amino-, hydrochloride, cis-
AC-6141
(1R,2S)-2-aminocyclohexanol hydrochloride
(cis)-2-aminocyclohexanol hydrochloride

MDL Number

MFCD00143981

Customs Code

29221990

FAQ

What are the physical and chemical properties of (1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6)?

(1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6) is a crystalline compound with a molecular weight of approximately 148.68 g/mol. It has a pKa of about 8.4 and is slightly soluble in water. The compound is known for its reactivity with bases, making it useful in various chemical reactions. It is also stable under normal conditions but should be stored in a cool, dry place to maintain its stability.

How is (1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6) typically synthesized?

(1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6) is typically synthesized via the hydrogenation of 2-chlorocyclohexanol followed by reaction with ammonia. This process leads to a high yield and good selectivity towards the (1R,2S) configuration. Commonly used catalysts include palladium on carbon under hydrogen pressure. The reaction is carried out under mild conditions, ensuring a safe and efficient process.

What industries use (1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6)?

(1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6) is commonly used in the pharmaceutical industry for the synthesis of various drugs due to its amine functionality. It also finds applications in the polymer industry for the modification of plastics and in the semiconductor industry for the production of precursors. Additionally, it is used in the fragrance industry to impart specific odor characteristics in perfumes and cosmetics.

What precautions should be taken when handling (1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6)?

When handling (1R,2S)-2-Aminocyclohexanol hydrochloride (CAS: 6936-47-6), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The substance should be handled in a well-ventilated area or under a fume hood to minimize inhalation risks. In case of a spill, neutralize any acidic residues with a base and dispose of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.