6-chloro-3-phenyl-pyridin-2-amine | CAS No. 69214-19-3
6-chloro-3-phenyl-pyridin-2-amine
Basic Information
CAS Number
69214-19-3
Molecular Formula
C11H9ClN2
Molecular Weight
204.66 g/mol
AD
Basic Physical Properties
Synonyms & References
English
- 6-chloro-3-phenyl-2-pyridinamine
- AKOS015891749
- A836394
- 6-chloranyl-3-phenyl-pyridin-2-amine
- DTXSID40355804
- FT-0611199
- 69214-19-3
- 2-Amino-6-chloro-3-phenylpyridine
- 2-Pyridinamine, 6-chloro-3-phenyl-
- SCHEMBL1901873
- AM1144
- 2-Pyridinamine,6-chloro-3-phenyl-
- 6-chloro-3-phenylpyridin-2-amine
- AC-8788
- 2-Pyridinamine,6-chloro-3-phenyl
- 6-amino-2-chloro-5-phenylpyridine
- 6-chloro-3-phenyl-2-aminopyridine
FAQ
What are the physical and chemical properties of 6-chloro-3-phenyl-pyridin-2-amine (CAS: 69214-19-3)?
6-Chloro-3-phenyl-pyridin-2-amine is a crystalline solid with a molecular weight of approximately 222.66 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal storage conditions but should be handled in a fume hood to avoid inhalation exposure.
How is 6-chloro-3-phenyl-pyridin-2-amine (CAS: 69214-19-3) typically synthesized?
6-Chloro-3-phenyl-pyridin-2-amine is typically synthesized via a multi-step process involving the protection of a pyridine nitrogen, followed by chlorination, and subsequent deprotection. Commonly, this involves the use of acetyl chloride for protection, N-chlorosuccinimide for chlorination, and TFA for deprotection. The overall yield is moderate, around 50-60%, depending on the purity of the intermediates.
What industries use 6-chloro-3-phenyl-pyridin-2-amine (CAS: 69214-19-3)?
6-Chloro-3-phenyl-pyridin-2-amine is primarily used in the pharmaceutical industry for the development of certain therapeutic agents. It is also utilized in research for the synthesis of other organic compounds, particularly those involving pyridine and phenyl groups. Its application in polymers and sensors is limited but ongoing research is exploring its potential in these areas.
What precautions should be taken when handling 6-chloro-3-phenyl-pyridin-2-amine (CAS: 69214-19-3)?
When handling 6-chloro-3-phenyl-pyridin-2-amine, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably in a fume hood, due to its potential for inhalation exposure. Spills should be cleaned up using absorbent materials and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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