6-chloro-3-phenyl-pyridin-2-amine(CAS: 69214-19-3)

6-Chloro-3-phenyl-pyridin-2-amine is a crystalline solid with a molecular weight of approximately 222.66 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal storage conditions but should be handled in a fume hood to avoid inhalation exposure.

6-Chloro-3-phenyl-pyridin-2-amine is typically synthesized via a multi-step process involving the protection of a pyridine nitrogen, followed by chlorination, and subsequent deprotection. Commonly, this involves the use of acetyl chloride for protection, N-chlorosuccinimide for chlorination, and TFA for deprotection. The overall yield is moderate, around 50-60%, depending on the purity of the intermediates.

6-Chloro-3-phenyl-pyridin-2-amine is primarily used in the pharmaceutical industry for the development of certain therapeutic agents. It is also utilized in research for the synthesis of other organic compounds, particularly those involving pyridine and phenyl groups. Its application in polymers and sensors is limited but ongoing research is exploring its potential in these areas.

When handling 6-chloro-3-phenyl-pyridin-2-amine, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably in a fume hood, due to its potential for inhalation exposure. Spills should be cleaned up using absorbent materials and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.