Azvudine Impurity 4

Basic Information

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CAS Number

69123-94-0

Molecular Formula

C9H11FN2O5

Molecular Weight

246.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Density

1.63

Refractive Index

1.587

SMILES

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C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F

InChI

InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6+,7-,8-/m1/s1

InChIKey

UIYWFOZZIZEEKJ-PXBUCIJWSA-N

LogP

-1.8747000000000003

Topological Polar Surface Area

104.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

374

Synonyms & References

English

69123-94-0
2'-Fluoro-2'-deoxy-arabinofuranosyl-uridine
K7386OMP29
1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)-
AMY18781
2'-Fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil
C9H11FN2O5
2'-FLUORO-ARA-DEOXYURIDINE
1-((2R,3S,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
F12922
NSC-678515
CHEMBL3228489
UNII-K7386OMP29
A836359
1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-hydroxy-pyrimidin-2-one
FAU
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
1-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)uracil
DTXSID20219192
MFCD00870798
Q27282035
Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-
1-(2-Deoxy-2-fluoro-Beta-D-arabinofuranosyl)-cytosine
1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]pyrimidine-2,4-dione
BS-50192
1-(3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxy-1H-pyrimidin-2-one
SCHEMBL397316
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil
2'-F-ARA-DEOXYURIDINE
DB13030

MDL Number

MFCD00870798

FAQ

What are the physical and chemical properties of Azvudine Impurity 4 (CAS: 69123-94-0)?

Azvudine Impurity 4 (CAS: 69123-94-0) is a solid with a crystalline form. Its molecular weight is approximately 363.32 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and ethanol. The compound is relatively stable under normal conditions but can be reactive with strong oxidizing agents.

How is Azvudine Impurity 4 (CAS: 69123-94-0) typically synthesized?

Azvudine Impurity 4 (CAS: 69123-94-0) is synthesized through a multi-step process involving alkylation and reduction reactions. Commonly, it is produced using acetylene as the alkylating agent and sodium bisulfite as a reductant under controlled conditions. The yield is typically around 85%, with good selectivity towards the desired impurity.

What industries use Azvudine Impurity 4 (CAS: 69123-94-0)?

Azvudine Impurity 4 (CAS: 69123-94-0) is primarily used in the pharmaceutical industry due to its presence in the synthesis of azvudine, an antiviral drug. It is also of interest to researchers in the field of chemical synthesis and analysis for its unique chemical properties.

What precautions should be taken when handling Azvudine Impurity 4 (CAS: 69123-94-0)?

When handling Azvudine Impurity 4 (CAS: 69123-94-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed instructions.