(2-Bromo-1,3-thiazol-5-yl)methanol

Basic Information

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CAS Number

687636-93-7

Molecular Formula

C4H4BrNOS

Molecular Weight

194.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

46-48

Boiling Point

288.3°C at 760 mmHg

Density

1.899

Flash Point

128.1°C

Refractive Index

1.575

SMILES

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C1=C(SC(=N1)Br)CO

InChI

InChI=1S/C4H4BrNOS/c5-4-6-1-3(2-7)8-4/h1,7H,2H2

InChIKey

DWNJWSPPORNJGV-UHFFFAOYSA-N

LogP

1.3979000000000001

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

82.4

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

(2-bromo-1,3-thiazol-5-yl)methanol
(2-bromo-thiazol-5-yl)-methanol
BP-13106
EN300-118628
2-Bromo-5-thiazolemethanol
J-500678
AB20494
(2-bromothiazol-5-yl)methanol;2-Bromothiazole-5-methanol
SY040567
5-Thiazolemethanol,2-bromo-
SCHEMBL606580
AKOS005255805
AM20100637
MFCD04115733
2-Bromothiazole-5-methanol
2-Bromo-5-hydroxymethylthiazole
CS-W008914
A836242
FS-2560
DTXSID00428422
687636-93-7
FT-0647245
DWNJWSPPORNJGV-UHFFFAOYSA-N
(2-bromothiazol-5-yl)methanol
5-Thiazolemethanol, 2-bromo-
(2-bromo-5-thiazolyl)methanol
RW4082
RP03943
2 - Bromo

MDL Number

MFCD04115733

Customs Code

2934100090

FAQ

What are the physical and chemical properties of (2-Bromo-1,3-thiazol-5-yl)methanol (CAS: 687636-93-7)?

(2-Bromo-1,3-thiazol-5-yl)methanol is a crystalline solid with a molecular weight of approximately 228.04 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. The compound is known for its reactivity, particularly towards nucleophiles and in condensation reactions. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

How is (2-Bromo-1,3-thiazol-5-yl)methanol (CAS: 687636-93-7) typically synthesized?

(2-Bromo-1,3-thiazol-5-yl)methanol is often synthesized via the condensation of thiazole and bromomethyl acetate. The reaction is typically carried out in a suitable solvent such as acetonitrile with a catalytic amount of a base like potassium carbonate. The yield can be increased by optimizing reaction conditions such as temperature and concentration. This compound is often used as a key intermediate in the synthesis of more complex organic molecules.

What industries use (2-Bromo-1,3-thiazol-5-yl)methanol (CAS: 687636-93-7)?

(2-Bromo-1,3-thiazol-5-yl)methanol finds application in the pharmaceutical industry as a building block for drug synthesis. It is also used in the development of sensors and as a precursor in the semiconductor industry. Its chemical properties make it suitable for use in polymer synthesis and as a reagent in analytical chemistry.

What precautions should be taken when handling (2-Bromo-1,3-thiazol-5-yl)methanol (CAS: 687636-93-7)?

When handling (2-Bromo-1,3-thiazol-5-yl)methanol, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place and away from sources of ignition. In case of a spill, it should be handled using appropriate containment and disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal procedures.