4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol

Basic Information

View in Editor

CAS Number

681482-81-5

Molecular Formula

C18H18F3NO3

Molecular Weight

353.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

C1CN(CCC1OC2=CC=C(C=C2)OC(F)(F)F)C3=CC=C(C=C3)O

InChI

InChI=1S/C18H18F3NO3/c19-18(20,21)25-17-7-5-15(6-8-17)24-16-9-11-22(12-10-16)13-1-3-14(23)4-2-13/h1-8,16,23H,9-12H2

InChIKey

KXHMPYHAQBAPJK-UHFFFAOYSA-N

LogP

4.338600000000003

Topological Polar Surface Area

41.93000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

397

Synonyms & References

English

SCHEMBL57855
1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine
A1-09453
1-(4-Hydroxyphenyl)-4-[4-(Trifluoromethoxy)phenoxy]piperidine
4-{4-[4-(trifluoromethoxy)phenoxy]piperidino}benzenol
SS-3227
DTXSID10470098
4-(4-[4-(Trifluoromethoxy)phenoxy]piperidino)phenol
CS-0326656
Phenol, 4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]-
4-(4-[4-(Trifluoromethoxy)phenoxy]piperidino)benzenol
4-[4-(4-Trifluoromethoxyphenoxy)piperidin-1-yl]phenol
4-(4-(4-(Trifluoromethoxy)phenoxy)piperidin-1-yl)phenol
681482-81-5
4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenol
AKOS005110868
4-[4-(4-trifluoromethoxyphenoxy)-piperidin-1-yl]phenol

MDL Number

MFCD16170437

FAQ

What are the physical and chemical properties of 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5)?

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is a crystalline compound with a molecular weight of approximately 490.04 g/mol. It has low water solubility and moderate solubility in organic solvents. The compound is relatively stable under normal conditions but may react with strong acids or bases. It is important to handle it under an inert atmosphere to prevent oxidation.

How is 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5) typically synthesized?

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is usually synthesized via multistep reactions involving coupling of a piperidine derivative with a 4-(trifluoromethoxy)phenol. Commonly, palladium-catalyzed cross-coupling reactions are used, with a high yield and good selectivity. The reaction conditions include the use of a ligand, a base, and an inert atmosphere.

What industries use 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5)?

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is primarily used in the pharmaceutical industry as an intermediate for the synthesis of active pharmaceutical ingredients. It may also find applications in polymer science and as a functional material for sensors and semiconductors.

What precautions should be taken when handling 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5)?

Handling 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored under an inert atmosphere and away from strong acids and bases. Spills should be cleaned up with caution, using appropriate safety protocols, and a Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.

Related Compounds

1,3-Dibromo-2,4-dichloro-5-fluorobenzene structure

Compound Q&A

What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?

6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one is a cyclic ketone with a molecular for...

21889-89-46-Methyl-7-oxabicycl...

Compound Q&A

What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?

4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid is a chemical compound with the CAS nu...

906353-00-24-[(6-Methyl-2-pyraz...

Compound Q&A

What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?

2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8) is a colorless to slightly yel...

49745-42-82-(2-Pyridinyl)-1,3-...

Compound Q&A

What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?

2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile is an organic compound with the CA...

24783-42-42-(6-Chloro-2-pyridi...

Compound Q&A

What is 2-Oxopropanamide (CAS: 631-66-3)?

2-Oxopropanamide, also known as 2-aminoacrylic acid, is a chemical compound with...

631-66-32-Oxopropanamide

Compound Q&A

What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?

2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CA...

1289040-88-52-Methyl-2-propanyl ...

Compound Q&A

What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?

NAMPT inhibitor-linker 1 (CAS: 2241019-57-6) is a chemical compound designed as ...

2241019-57-6NAMPT inhibitor-link...

Compound Q&A

What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?

It is a chemical compound with the structure (2-(2,2,2-Trifluoroacetyl)pyridin-4...

1310404-58-0(2-(2,2,2-Trifluoroa...

Compound Q&A

What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?

1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,...

794568-90-41-(2-Chlorophenyl)-6...

Compound Q&A

What is Vinyl(chloromethyl)dimethoxysilane (CAS: 1314981-48-0)?

Vinyl(chloromethyl)dimethoxysilane is an organosilicon compound with the molecul...

1314981-48-0Vinyl(chloromethyl)d...

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol | CAS No. 681482-81-5

Basic Information

CAS Number

Molecular Formula

Molecular Weight

Chemical Classification

Basic Physical Properties

Chemical Properties

SMILES

InChI

InChIKey

LogP

Topological Polar Surface Area

Hydrogen Bond Donor/Acceptor

Complexity

Synonyms & References

English

MDL Number

FAQ

What are the physical and chemical properties of 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5)?

How is 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5) typically synthesized?

What industries use 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5)?

What precautions should be taken when handling 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5)?

Related Compounds

You might also like

What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?

What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?

What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?

What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?

What is 2-Oxopropanamide (CAS: 631-66-3)?

What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?

What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?

What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?

What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?

What is Vinyl(chloromethyl)dimethoxysilane (CAS: 1314981-48-0)?

Supplier Information

Tianjin Hengze Pharmaceutical Technology Co., Ltd.

Chengdu Yehang Technology Co., Ltd.

Hangzhou Yaorieyicheng Biopharmaceutical Co., Ltd.

Shanghai Hansi Chemical Co., Ltd.

Jin Jinle (Hunan) Chemical Co., Ltd.

Hubei Shixing Chemical Co., Ltd.

HuBeiGuoYunFuRui Technology Co Ltd

ShenZhenAiTaHuaXue Co Ltd

Hubei Nona Technology Co., Ltd.

Shanghai Kewei Chemical Technology Co., Ltd.

JiangSuAiKangShengWuYiYaoYanFa Co Ltd

XiAnJiangHua Biotechnology Co Ltd

Shanghai Jieshukai Biotechnology Co., Ltd.

Prisun Pharmatech Co.,Ltd.

Product Inquiry