Compound Q&A
How is 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol (CAS: 681482-81-5) typically synthesized?
Answer
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4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is usually synthesized via multistep reactions involving coupling of a piperidine derivative with a 4-(trifluoromethoxy)phenol. Commonly, palladium-catalyzed cross-coupling reactions are used, with a high yield and good selectivity. The reaction conditions include the use of a ligand, a base, and an inert atmosphere.
About
CAS No
681482-81-5
English Name
4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol
Molecular Formula
C18H18F3NO3
Molecular Weight
353.34 g/mol
SMILES
C1CN(CCC1OC2=CC=C(C=C2)OC(F)(F)F)C3=CC=C(C=C3)O
InChIKey
KXHMPYHAQBAPJK-UHFFFAOYSA-N
Last Updated: 2026-01-01 01:49
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