4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol(CAS: 681482-81-5)

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is a crystalline compound with a molecular weight of approximately 490.04 g/mol. It has low water solubility and moderate solubility in organic solvents. The compound is relatively stable under normal conditions but may react with strong acids or bases. It is important to handle it under an inert atmosphere to prevent oxidation.

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is usually synthesized via multistep reactions involving coupling of a piperidine derivative with a 4-(trifluoromethoxy)phenol. Commonly, palladium-catalyzed cross-coupling reactions are used, with a high yield and good selectivity. The reaction conditions include the use of a ligand, a base, and an inert atmosphere.

4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol is primarily used in the pharmaceutical industry as an intermediate for the synthesis of active pharmaceutical ingredients. It may also find applications in polymer science and as a functional material for sensors and semiconductors.

Handling 4-{4-[4-(Trifluoromethoxy)phenoxy]-1-piperidinyl}phenol requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored under an inert atmosphere and away from strong acids and bases. Spills should be cleaned up with caution, using appropriate safety protocols, and a Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.