4'-Deoxy Vincristine

Basic Information

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CAS Number

68135-16-0

Molecular Formula

C46H56N4O9

Molecular Weight

809 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

186-188°C

SMILES

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CCC1CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC

InChI

InChI=1S/C46H56N4O9/c1-7-28-20-29-23-45(41(53)57-5,37-31(14-18-48(24-28)25-29)30-12-9-10-13-34(30)47-37)33-21-32-35(22-36(33)56-4)50(26-51)39-44(32)16-19-49-17-11-15-43(8-2,38(44)49)40(59-27(3)52)46(39,55)42(54)58-6/h9-13,15,21-22,26,28-29,38-40,47,55H,7-8,14,16-20,23-25H2,1-6H3/t28-,29-,38+,39-,40-,43-,44-,45+,46+/m1/s1

InChIKey

KLFUUCHXSFIPMH-VSBPWMKXSA-N

LogP

4.402600000000004

Topological Polar Surface Area

150.94000000000003 Å²

Hydrogen Bond Donor/Acceptor

2 / 13

Complexity

1700

Synonyms & References

English

4'-Deoxy Vincristine
4'-Deoxy-22-oxo-vincaleukoblastine
DTXSID70601962
PUBCHEM_20055311
68135-16-0
Methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17R)-17-ethyl-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
SCHEMBL285304
4´-Deoxy Vincristine
4?-Deoxy Vincristine
4-acetoxy-1-formyl-3-hydroxy-16-methoxy-15-(18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester

FAQ

What is 4'-Deoxy Vincristine (CAS: 68135-16-0)?

4'-Deoxy Vincristine, also known as 4'-Deoxyvincristine, is an anticancer drug derived from the plant Catharanthus roseus. It has a molecular formula of C22H21NO4 and a CAS number of 68135-16-0. This compound exhibits antimitotic activity, inhibiting cell division and is commonly used in cancer chemotherapy.

What are the main uses of 4'-Deoxy Vincristine (CAS: 68135-16-0)?

4'-Deoxy Vincristine (CAS: 68135-16-0) is primarily used in the treatment of various cancers, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, and acute lymphoblastic leukemia. It is also used in combination therapies to enhance treatment efficacy.

Is 4'-Deoxy Vincristine (CAS: 68135-16-0) safe?

4'-Deoxy Vincristine (CAS: 68135-16-0) is generally considered safe when used under medical supervision. However, it can cause side effects such as peripheral neuropathy, bone marrow suppression, and gastrointestinal issues. Proper handling and administration by healthcare professionals are essential to minimize risks.

How should 4'-Deoxy Vincristine (CAS: 68135-16-0) be stored?

4'-Deoxy Vincristine (CAS: 68135-16-0) should be stored at a temperature between 2°C and 8°C (36°F to 46°F) to maintain its stability. It should be protected from light and stored in a tightly sealed container to prevent degradation. Avoid exposure to heat and moisture.