2-Chloro-N-methoxy-N-methylacetamide

Basic Information

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CAS Number

67442-07-3

Molecular Formula

C4H8ClNO2

Molecular Weight

137.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

37.0 to 41.0 deg-C

Boiling Point

95°C/9mmHg

Density

1.178±0.06 g/cm3 (20 ºC 760 Torr),

Water Solubility

Insoluble in water.

Refractive Index

1.442

SMILES

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CN(C(=O)CCl)OC

InChI

InChI=1S/C4H8ClNO2/c1-6(8-2)4(7)3-5/h3H2,1-2H3

InChIKey

SCOJKGRNQDKFRP-UHFFFAOYSA-N

LogP

0.24499999999999988

Topological Polar Surface Area

29.54 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

86.1

Safety Information

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GHS Hazard Pictograms

H302

H312

H332

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H332 Harmful if inhaled
Acute toxicity, inhalation

Synonyms & References

English

EN300-93211
2-Chloro-N-methoxy-N-methylacetamide, 98%
UNII-2V3FHW6LWF
N-methyloxy-N-methyl-2-chloroacetamide
674420-70-3
F1903-0107
NS00005318
chloroacetic acid N-methyl-N-methoxy-amide
Methyl 2-Chloro-N-methylacetohydroxamate
.ALPHA.-CHLORO-N-METHOXY-N-METHYLACETAMIDE
Acetamide, 2-chloro-N-methoxy-N-methyl-
MFCD00134232
EC 629-377-5
2-Chloro-N-methoxy-N-methylacetamide
CS-W001106
DTXSID90370461
C2272
SCHEMBL98900
N-Methyl-N-methoxy-2-chloroacetamide
2-CHLORO N-METHOXY N METHYL ACETAMIDE
AC-28975
A835752
AM20100624
2-Chloro-N-methoxy-N-methyl acetamide
2-chloro-N-methoxy-N-methyl-acetamide
AKOS005207299
SY002384
SCOJKGRNQDKFRP-UHFFFAOYSA-N
67442-07-3
2V3FHW6LWF
FT-0611981

MDL Number

MFCD00134232

Customs Code

2924199090

FAQ

What are the physical and chemical properties of 2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3)?

2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3) is a white crystalline solid with a molecular weight of approximately 161.58 g/mol. It has a melting point of 78-79°C and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is a reactive compound, particularly in nucleophilic substitution reactions at the chlorine atom.

How is 2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3) typically synthesized?

2-Chloro-N-methoxy-N-methylacetamide is typically synthesized via nucleophilic substitution reactions. The reaction involves the chlorination of methyl acetamide in the presence of methanol and a phase-transfer catalyst like tetra-n-butylammonium chloride. The synthetic route provides good selectivity and yields up to 85%.

What industries use 2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3)?

2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3) is used in various industries, particularly in pharmaceuticals for synthetic intermediates and drug development. It also finds applications in polymer chemistry for certain types of plastic synthesis, and in the electronics industry for semiconductor materials and sensors.

What precautions should be taken when handling 2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3)?

When handling 2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be handled by sweeping into a container and disposing of according to local regulations. Always refer to a Safety Data Sheet (SDS) for detailed handling and emergency procedures.