2-Chloro-N-methoxy-N-methylacetamide(CAS: 67442-07-3)

2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3) is a white crystalline solid with a molecular weight of approximately 161.58 g/mol. It has a melting point of 78-79°C and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is a reactive compound, particularly in nucleophilic substitution reactions at the chlorine atom.

2-Chloro-N-methoxy-N-methylacetamide is typically synthesized via nucleophilic substitution reactions. The reaction involves the chlorination of methyl acetamide in the presence of methanol and a phase-transfer catalyst like tetra-n-butylammonium chloride. The synthetic route provides good selectivity and yields up to 85%.

2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3) is used in various industries, particularly in pharmaceuticals for synthetic intermediates and drug development. It also finds applications in polymer chemistry for certain types of plastic synthesis, and in the electronics industry for semiconductor materials and sensors.

When handling 2-Chloro-N-methoxy-N-methylacetamide (CAS: 67442-07-3), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be handled by sweeping into a container and disposing of according to local regulations. Always refer to a Safety Data Sheet (SDS) for detailed handling and emergency procedures.