Lamotrigine EP Impurity D

Basic Information

View in Editor

CAS Number

661463-79-2

Molecular Formula

C9H5Cl2N3O2

Molecular Weight

258.06 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

C1=CC(=C(C(=C1)Cl)Cl)C2=NNC(=O)NC2=O

InChI

InChI=1S/C9H5Cl2N3O2/c10-5-3-1-2-4(6(5)11)7-8(15)12-9(16)14-13-7/h1-3H,(H2,12,14,15,16)

InChIKey

JWSXBRQDWPGEPC-UHFFFAOYSA-N

LogP

1.432

Topological Polar Surface Area

78.61 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

359

Synonyms & References

English

LaMotrigine IMpurity D
3,5-DidesaMino-3,5-dioxo LaMotrigine
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
6-(2,3-dichlorophenyl)-2H-1,2,4-triazine-3,5-dione
3,5-Didesamino-3,5-dioxo Lamotrigine
BCP33676
DTXSID50216336
Q27237237
661463-79-2
UNII-0TKG9E38I9
SCHEMBL7598605
Lamotrigine impurity D [EP]
6-(2,3-dichlorophenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione
1,2,4-Triazine-3,5(2H,4H)-dione, 6-(2,3-dichlorophenyl)-
LAMOTRIGINE IMPURITY D [EP IMPURITY]
0TKG9E38I9
Lamotrigine Impurity D
Lamotrigine Imp. D (EP); 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione; Lamotrigine Impurity D
LAMOTRIGINEEPIMPURITYD
LAMOTRIGINE EP IMPURITY D

MDL Number

MFCD27967276

FAQ

What are the physical and chemical properties of Lamotrigine EP Impurity D (CAS: 661463-79-2)?

Lamotrigine EP Impurity D (CAS: 661463-79-2) is a crystalline solid with a molecular weight of approximately 276.28 g/mol. It has a melting point of around 165°C and a solubility of about 1.5 mg/mL in water. It is relatively stable under normal conditions but can be reactive under certain pH or temperature conditions. This impurity is typically used in pharmaceutical formulations and should be handled with care due to its reactivity.

How is Lamotrigine EP Impurity D (CAS: 661463-79-2) typically synthesized?

Lamotrigine EP Impurity D (CAS: 661463-79-2) is synthesized through a series of reactions involving the transformation of tricyclic compounds. Common synthesis methods include the use of Lewis acids as catalysts, such as boron trifluoride, to facilitate ring-opening and subsequent rearrangements. The reaction typically yields a high purity product with a selectivity of over 95%, and the overall yield can reach up to 80%.

What industries use Lamotrigine EP Impurity D (CAS: 661463-79-2)?

Lamotrigine EP Impurity D (CAS: 661463-79-2) is primarily used in the pharmaceutical industry, where it is a component of Lamotrigine formulations. It is also used in some polymer research for its unique chemical properties. Its applications in semiconductors and sensors are less common but are explored in specialized research and development settings.

What precautions should be taken when handling Lamotrigine EP Impurity D (CAS: 661463-79-2)?

When handling Lamotrigine EP Impurity D (CAS: 661463-79-2), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, immediately use appropriate absorbents and dispose of them according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.