Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate | CAS No. 660406-89-3
Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate
Basic Information
CAS Number
660406-89-3
Molecular Formula
C12H18N2O3
Molecular Weight
227.3 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- tert-Butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate
- 1-Boc-3-(cyanoacetyl)pyrrolidine
- tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate
- AKOS022182182
- SCHEMBL6223051
- 1-BOC-3-(CYANOACETYL)PYRROLIDINE
- tert-Butyl 3-(cyanoacetyl)pyrrolidine-1-carboxylate
- 3-(2-CYANO-ACETYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- DB-261590
- AMY17305
- 3-(1-Boc-3-pyrrolidinyl)-3-oxopropanenitrile
- AS-44709
- 660406-89-3
- TERT-BUTYL 3-(2-CYANOACETYL)PYRROLIDINE-1-CARBOXYLATE
- CS-0055248
- MFCD09953053
- AB3356
- SY268468
- TERT-BUTYL 3-CYANOACETYL-1-PYRROLIDINECARBOXYLATE
- AKOS005266495
- TERT-BUTYL3-(2-CYANOACETYL)PYRROLIDINE-1-CARBOXYLATE
- DTXSID20624060
- PB17708
MDL Number
MFCD09953053
FAQ
What are the physical and chemical properties of Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate (CAS: 660406-89-3)?
Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate is a white crystalline solid with a molecular weight of approximately 293.35 g/mol. It has a pKa of around 4 and is moderately soluble in common organic solvents such as dichloromethane and acetonitrile. The compound is highly reactive towards nucleophiles, showing good reactivity in ester and amide formations. It is stable under normal conditions but should be stored in a cool, dry place away from moisture and direct sunlight.
How is Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate (CAS: 660406-89-3) typically synthesized?
Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate is typically synthesized via the condensation of tert-butyl pyrrolidine-1-carboxylate with 2-cyanopropionyl chloride in the presence of a catalyst such as 4-(dimethylamino)pyridine (DMAP) and a phase transfer catalyst like tetrabutylammonium bromide (TBAB). The reaction yields a high purity product with good selectivity and yield, making it a reliable method for industrial production.
What industries use Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate (CAS: 660406-89-3)?
Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate is primarily used in the pharmaceutical industry for the synthesis of drugs and intermediates. It is also utilized in the polymer industry for the development of functional polymers and in the sensor industry for the production of chemically sensitive materials. Its reactivity and functional groups make it a valuable compound in various applications.
What precautions should be taken when handling Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate (CAS: 660406-89-3)?
When handling Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood due to its reactivity. Spills should be cleaned up immediately using absorbent materials and appropriate waste should be disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed safety information.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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