Compound Q&A
How is Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate (CAS: 660406-89-3) typically synthesized?
Answer
Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate is typically synthesized via the condensation of tert-butyl pyrrolidine-1-carboxylate with 2-cyanopropionyl chloride in the presence of a catalyst such as 4-(dimethylamino)pyridine (DMAP) and a phase transfer catalyst like tetrabutylammonium bromide (TBAB). The reaction yields a high purity product with good selectivity and yield, making it a reliable method for industrial production.
About
CAS No
660406-89-3
English Name
Tert-butyl 3-(2-cyanoacetyl)pyrrolidine-1-carboxylate
Molecular Formula
C12H18N2O3
Molecular Weight
227.3 g/mol
SMILES
CC(C)(C)OC(=O)N1CCC(C1)C(=O)CC#N
InChIKey
PCLWTBWRXMOPOV-UHFFFAOYSA-N
Last Updated: 2026-04-02 00:18
