(E)-Naftifine | CAS No. 65472-88-0

(E)-Naftifine

Basic Information

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CAS Number

65472-88-0

Molecular Formula

C21H21N

Molecular Weight

287.41 g/mol

Chemical Classification

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

177 °C

Boiling Point

bp0.015 torr 162-167°

SMILES

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CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32

InChI

InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3

InChIKey

OZGNYLLQHRPOBR-UHFFFAOYSA-N

LogP

4.985000000000004

Topological Polar Surface Area

3.24 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

342

Synonyms & References

English

AC-22577
(E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-prop-2-en-1-amine
CHEMBL626
1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, (Z)-
BPBio1_001152
BSPBio_001046
CHEBI:7451
1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, (E)-
NAFTIFINE [WHO-DD]
trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine
Prestwick3_001063
(E)-N-Cinnamyl-N-methyl-1-naphthylmethylamin
Naftifine (INN)
UNII-4FB1TON47A
(E)-N-Cinnamyl-N-methyl-1-naphthalinmethylamin
A934003
AKOS025310693
4FB1TON47A
Naftifina (INN-Spanish)
DTXSID6048545
AB00514711
Methyl-naphthalen-1-ylmethyl-(3-phenyl-allyl)-amine
Naftifinum (INN-Latin)
BRD-K74141488-003-03-9
Naft-500
NCGC00179332-01
D01AE22
Naftifina
SCHEMBL3692459
Naftifine [INN:BAN]
C08071

MDL Number

MFCD00865622

Customs Code

2921499090

FAQ

What are the physical and chemical properties of (E)-Naftifine (CAS: 65472-88-0)?

(E)-Naftifine is a white crystalline solid with a molecular weight of approximately 296.34 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It is not highly reactive under normal conditions but requires careful handling to avoid degradation.

How is (E)-Naftifine (CAS: 65472-88-0) typically synthesized?

(E)-Naftifine is typically synthesized via a multi-step process involving the reaction of 2-naphthol with a ketone, followed by hydrogenation and subsequent functional group transformations. The reaction involves the use of a palladium catalyst and is carried out under optimized conditions to achieve high selectivity and yield. The process is complex and requires strict control over temperature and reaction time.

What industries use (E)-Naftifine (CAS: 65472-88-0)?

(E)-Naftifine is primarily used in the pharmaceutical industry as an antifungal agent. It is also explored in the cosmetics industry for its antifungal properties. Research is ongoing in other sectors such as polymer science and drug delivery systems, although its main application remains in pharmaceuticals.

What precautions should be taken when handling (E)-Naftifine (CAS: 65472-88-0)?

When handling (E)-Naftifine, it is crucial to use proper personal protective equipment (PPE), including gloves and safety glasses. Always work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbents and neutralizers, and the area should be thoroughly cleaned. Refer to the Safety Data Sheet (SDS) for detailed instructions and emergency procedures.