Urapidil hydrochloride

Basic Information

View in Editor

CAS Number

64887-14-5

Molecular Formula

C20H30ClN5O3

Molecular Weight

423.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

156-1580C

Boiling Point

549°C at 760 mmHg

Flash Point

285.8 °C

Solubility

H2O: soluble

SMILES

View in Editor

CN1C(=CC(=O)N(C1=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC.Cl

InChI

InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H

InChIKey

KTMLZVUAXJERAT-UHFFFAOYSA-N

LogP

1.1385999999999994

Topological Polar Surface Area

71.74000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

588

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

FT-0675734
Pharmakon1600-01503100
LP01265
Tox21_501265
6-((3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride
Urapidil HCl
SR-01000075295-10
AKOS015994621
SR-01000075295-9
SMR000058525
HMS1570F12
NCGC00261950-01
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione;hydrochloride
DTXSID2045812
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
CAS-64887-14-5
NSC758226
D08662
NCGC00094502-01
6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride
HY-B0354A
MFCD00078601
6[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride
NC00048
SW197244-4
SR-01000075295
URAPIDIL HYDROCHLORIDE [WHO-DD]
NCGC00016066-14
UNII-PVU92PZO12
Urapidil hydrochloride
NSC-758226

MDL Number

MFCD00078601

Customs Code

3004909090

FAQ

What are the physical and chemical properties of Urapidil hydrochloride (CAS: 64887-14-5)?

Urapidil hydrochloride is a white to off-white crystalline powder with a molecular weight of approximately 271.79 g/mol. It has a solubility of 1175 mg/mL in water and is practically insoluble in ethanol. It is slightly basic in nature and exhibits good stability under normal storage conditions. It reacts with strong acids but is stable under neutral and basic conditions.

How is Urapidil hydrochloride (CAS: 64887-14-5) typically synthesized?

Urapidil hydrochloride is synthesized by a multi-step process starting from 2-(2-aminoethyl)-1,3-propanediol. The key steps include amide formation, hydrochloride salt formation, and crystallization. The synthesis involves the use of acetic anhydride, hydrochloric acid, and other reagents. The yield is typically around 85% with good selectivity.

What industries use Urapidil hydrochloride (CAS: 64887-14-5)?

Urapidil hydrochloride is primarily used in the pharmaceutical industry. It is an antihypertensive and anti-anginal agent used in the treatment of hypertension and angina pectoris. It is also studied for its potential applications in neurology and psychiatry. While not widely used in other industries, it may have future applications in drug delivery systems and sensors.

What precautions should be taken when handling Urapidil hydrochloride (CAS: 64887-14-5)?

When handling Urapidil hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store it in a cool, dry place, away from direct sunlight and heat sources. Ensure good ventilation when handling. In case of skin contact, wash with soap and water. In case of inhalation, move to fresh air immediately. Refer to the Safety Data Sheet (SDS) for more detailed handling and emergency procedures.