Urapidil hydrochloride(CAS: 64887-14-5)

Urapidil hydrochloride is a white to off-white crystalline powder with a molecular weight of approximately 271.79 g/mol. It has a solubility of 1175 mg/mL in water and is practically insoluble in ethanol. It is slightly basic in nature and exhibits good stability under normal storage conditions. It reacts with strong acids but is stable under neutral and basic conditions.

Urapidil hydrochloride is synthesized by a multi-step process starting from 2-(2-aminoethyl)-1,3-propanediol. The key steps include amide formation, hydrochloride salt formation, and crystallization. The synthesis involves the use of acetic anhydride, hydrochloric acid, and other reagents. The yield is typically around 85% with good selectivity.

Urapidil hydrochloride is primarily used in the pharmaceutical industry. It is an antihypertensive and anti-anginal agent used in the treatment of hypertension and angina pectoris. It is also studied for its potential applications in neurology and psychiatry. While not widely used in other industries, it may have future applications in drug delivery systems and sensors.

When handling Urapidil hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store it in a cool, dry place, away from direct sunlight and heat sources. Ensure good ventilation when handling. In case of skin contact, wash with soap and water. In case of inhalation, move to fresh air immediately. Refer to the Safety Data Sheet (SDS) for more detailed handling and emergency procedures.