Tizanidine hydrochloride

Basic Information

View in Editor

CAS Number

64461-82-1

Molecular Formula

C9H9Cl2N5S

Molecular Weight

290.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

280°C

Boiling Point

391.2 ºC at 760 mmHg

Flash Point

9℃

Solubility

H2O: ~29 mg/mL

SMILES

View in Editor

C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl.Cl

InChI

InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H

InChIKey

ZWUKMNZJRDGCTQ-UHFFFAOYSA-N

LogP

2.1375999999999995

Topological Polar Surface Area

62.2 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

300

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DS 103-282
DS-103282 ch
Tox21_501114
NC00654
TIZANIDINE HYDROCHLORIDE (MART.)
B53E3NMY5C
TIZANIDINE HYDROCHLORIDE [USP IMPURITY]
MFCD00798231
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole hydrochloride
TIZANIDINE HYDROCHLORIDE [USP MONOGRAPH]
Tizanidine hydrochloride (USAN:USP:JAN)
CHEBI:9609
TIZANIDINE HYDROCHLORIDE [JAN]
5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
DS-103282
Tizanidine hydrochloride, >=98% (HPLC), powder
NS00076464
SR-01000765392
TIZANIDINE HYDROCHLORIDE [USAN]
BCP28540
TIZANIDINE HYDROCHLORIDE [ORANGE BOOK]
D70434
CCG-220602
2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride
SR-01000765392-4
(5-chloro-2,1,3-benzothiadiazol-4-yl)-(4,5-dihydro-1H-imidazol-2-yl)azanium;chloride
TIZANIDINE HYDROCHLORIDE (EP MONOGRAPH)
SMR000499584
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole monohydrochloride
Tizanidne Hydrochloride
SCHEMBL41199

MDL Number

MFCD00798231

Customs Code

2934300000

FAQ

What are the physical and chemical properties of Tizanidine hydrochloride (CAS: 64461-82-1)?

Tizanidine hydrochloride is a white or almost white crystalline powder with a molecular weight of approximately 250.79 g/mol. It is slightly soluble in water and practically insoluble in ethanol. This compound is not very reactive under normal conditions but can be hydrolyzed under basic conditions. The CAS number is 64461-82-1.

How is Tizanidine hydrochloride (CAS: 64461-82-1) typically synthesized?

Tizanidine hydrochloride is usually synthesized via a multi-step process starting from 6-methyl-6-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid. The key steps include condensation, reduction, and finally conversion to hydrochloride salt. The yield is typically around 85-90%, and the process requires careful control of pH and temperature. The CAS number is 64461-82-1.

What industries use Tizanidine hydrochloride (CAS: 64461-82-1)?

Tizanidine hydrochloride is primarily used in the pharmaceutical industry as a muscle relaxant. It is also applicable in the medical field for the treatment of neuropathic pain and hypertension. The CAS number is 64461-82-1.

What precautions should be taken when handling Tizanidine hydrochloride (CAS: 64461-82-1)?

When handling Tizanidine hydrochloride, it is important to wear appropriate personal protective equipment such as gloves and safety glasses. Ensure the work is conducted in a well-ventilated area or a fume hood. In case of a spill, neutralize the acid with a base and dispose of according to local regulations. Always refer to the safety data sheet (SDS) for detailed precautions. The CAS number is 64461-82-1.