m-PEG4-NHS ester

Basic Information

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CAS Number

622405-78-1

Molecular Formula

C14H23NO8

Molecular Weight

333.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Density

1.23±0.1 g/cm3 (20 ºC 760 Torr),

SMILES

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COCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

InChI

InChI=1S/C14H23NO8/c1-19-6-7-21-10-11-22-9-8-20-5-4-14(18)23-15-12(16)2-3-13(15)17/h2-11H2,1H3

InChIKey

MAYFFZZPEREGBQ-UHFFFAOYSA-N

LogP

-0.3200999999999987

Topological Polar Surface Area

100.6 Å²

Hydrogen Bond Donor/Acceptor

0 / 9

Complexity

371

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propanoate
N-Succinimidyl 4,7,10,13-Tetraoxatetradecanoate
M2186
N-hydroxysuccinimidyl 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propanoate
4,7,10,13-Tetraoxatetradecanoic Acid N-Succinimidyl Ester
1-(4,7,10,13-tetraoxatetradecan-1-oyloxy)pyrrolidine-2,5-dione
Methyl-PEG4-NHS Ester
AmbotzPEG1880
mPEG3-NHS
mPEG3-NHS Ester
mPEG4-NHS Ester
1-[(1-Oxo-4,7,10,13-tetraoxatetradec-1-yl)oxy]-2,5-pyrrolidinedione
m-PEG4-NHS ester
Methyl-PEG4-NHSEster
Methyl-(PEG)4-NHS
m-dPEG(R)4-NHS ester
mPEG3-CH2CH2COONHS Ester
BIPG1622
MAYFFZZPEREGBQ-UHFFFAOYSA-N
AK176356
4,7,10,13-Tetraoxatetradecanoic
2,5-Dioxopyrrolidin-1-yl 2,5,8,11-tetraoxatetradecan-14-oate
N-Succinimid
CS-0086204
622405-78-1
mPEG3-SPA
C70355
Succinimidyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate
MFCD11041112
m-PEG4 NHS Ester
MPEG3-NHS

MDL Number

MFCD11041112

FAQ

What are the physical and chemical properties of m-PEG4-NHS ester (CAS: 622405-78-1)?

m-PEG4-NHS ester (CAS: 622405-78-1) is a water-soluble compound with a molecular weight of approximately 5,000 Da. It has a pKa of about 8.0, making it amphoteric. This NHS ester functionalized polymer reacts readily with primary amines to form stable amide bonds. It is soluble in water and common organic solvents. Its crystalline form is not common; typically, it is supplied as a solution or as a lyophilized powder.

How is m-PEG4-NHS ester (CAS: 622405-78-1) typically synthesized?

m-PEG4-NHS ester (CAS: 622405-78-1) is synthesized by reacting polyethylene glycol (PEG) with N-hydroxysuccinimide (NHS) ester. The reaction is typically catalyzed by a carbodiimide such as EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The reaction yields a high degree of selectivity and provides a clean product with high yield. The process is often carried out in a solvent such as DCM (dichloromethane) or DMF (dimethylformamide).

What industries use m-PEG4-NHS ester (CAS: 622405-78-1)?

m-PEG4-NHS ester (CAS: 622405-78-1) is widely used in pharmaceuticals for drug conjugation and drug delivery systems. It is also used in polymer chemistry for polymer modification, in biosensors for immobilizing biomolecules, and in semiconductor industry for surface functionalization.

What precautions should be taken when handling m-PEG4-NHS ester (CAS: 622405-78-1)?

When handling m-PEG4-NHS ester (CAS: 622405-78-1), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood due to its reactivity. Spills should be cleaned up with caution, using appropriate absorbent materials. Safety data sheets (SDS) should be consulted for detailed handling instructions and emergency procedures. Proper disposal of waste should be managed according to local regulations to ensure environmental safety.