m-PEG4-NHS ester(CAS: 622405-78-1)

m-PEG4-NHS ester (CAS: 622405-78-1) is a water-soluble compound with a molecular weight of approximately 5,000 Da. It has a pKa of about 8.0, making it amphoteric. This NHS ester functionalized polymer reacts readily with primary amines to form stable amide bonds. It is soluble in water and common organic solvents. Its crystalline form is not common; typically, it is supplied as a solution or as a lyophilized powder.

m-PEG4-NHS ester (CAS: 622405-78-1) is synthesized by reacting polyethylene glycol (PEG) with N-hydroxysuccinimide (NHS) ester. The reaction is typically catalyzed by a carbodiimide such as EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The reaction yields a high degree of selectivity and provides a clean product with high yield. The process is often carried out in a solvent such as DCM (dichloromethane) or DMF (dimethylformamide).

m-PEG4-NHS ester (CAS: 622405-78-1) is widely used in pharmaceuticals for drug conjugation and drug delivery systems. It is also used in polymer chemistry for polymer modification, in biosensors for immobilizing biomolecules, and in semiconductor industry for surface functionalization.

When handling m-PEG4-NHS ester (CAS: 622405-78-1), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood due to its reactivity. Spills should be cleaned up with caution, using appropriate absorbent materials. Safety data sheets (SDS) should be consulted for detailed handling instructions and emergency procedures. Proper disposal of waste should be managed according to local regulations to ensure environmental safety.