Nortriptyline EP Impurity E HCl (Amitriptyline EP Impurity B HCl)

Basic Information

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CAS Number

6202-23-9

Molecular Formula

C20H22ClN

Molecular Weight

311.86 g/mol

Chemical Classification

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

215.0 to 219.0 deg-C

SMILES

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CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31.Cl

InChI

InChI=1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

InChIKey

VXEAYBOGHINOKW-UHFFFAOYSA-N

LogP

4.975600000000005

Topological Polar Surface Area

3.24 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

365

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova)

Synonyms & References

English

Flexeril (TN)
5-[3-(Dimethylamino)propylidene]-5H-dibenzo-[a,d]cycloheptene hydrochloride
Cyclobenzaprine HCLER
VXEAYBOGHINOKW-UHFFFAOYSA-N
3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-aminehydrochloride
Tox21_110040_1
CAS-6202-23-9
NSC 78206
NSC-169900
NSC-173379
Cyclobenzaprine.HCl
NSC169900
Cyclobenzaprine (hydrochloride)
CYCLOBENZAPRINE HYDROCHLORIDE [USP MONOGRAPH]
AS-15745
N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Delta(5,gamma)-propylamine hydrochloride
EUR-1002
Miosan
CYCLOBENZAPRINE HCI
Cyclobenzaprine HCL ER
FR2100873
NSC-758414
Pharmakon1600-01503207
NCGC00095017-01
SB19022
Cyclobenzaprine hydrochloride [USAN:USP]
WLN: L C676 BHJ B3N1&1 &GH
10,11delta-Amitriptyline hydrochloride
10,11.delta.-Amitriptyline hydrochloride
CYCLOBENZAPRINE HYDROCHLORIDE (USP MONOGRAPH)
NSC78206

MDL Number

MFCD00079039

Customs Code

2942000000

FAQ

What are the physical and chemical properties of Nortriptyline EP Impurity E HCl (CAS: 6202-23-9)?

Nortriptyline EP Impurity E HCl is a crystalline solid with a molecular weight of approximately 342.81 g/mol. It is slightly soluble in water and has limited solubility in common organic solvents. This compound is less reactive compared to its parent compound, nortriptyline. It is stable under normal conditions but should be stored away from moisture and heat to prevent degradation.

How is Nortriptyline EP Impurity E HCl (CAS: 6202-23-9) typically synthesized?

Nortriptyline EP Impurity E HCl is synthesized through a series of steps involving the reduction of nortriptyline to its hydrochloride salt. Commonly, this involves the use of a hydrogenation catalyst such as palladium on carbon. The process typically achieves a high yield, with selectivity towards the desired impurity isomer. The reaction is performed under mild conditions to ensure the formation of the correct isomer.

What industries use Nortriptyline EP Impurity E HCl (CAS: 6202-23-9)?

Nortriptyline EP Impurity E HCl is primarily used in the pharmaceutical industry for the synthesis and quality control of antidepressants. While it has limited direct applications, it plays a crucial role in the development and manufacturing of pharmaceutical products. Additionally, it may find use in analytical chemistry for impurity profiling and quality assurance purposes.

What precautions should be taken when handling Nortriptyline EP Impurity E HCl (CAS: 6202-23-9)?

When handling Nortriptyline EP Impurity E HCl, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be immediately cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.