Compound Q&A

How is Nortriptyline EP Impurity E HCl (CAS: 6202-23-9) typically synthesized?

Answer

Nortriptyline EP Impurity E HCl (Amitriptyline EP Impurity B HCl)
Nortriptyline EP Impurity E HCl is synthesized through a series of steps involving the reduction of nortriptyline to its hydrochloride salt. Commonly, this involves the use of a hydrogenation catalyst such as palladium on carbon. The process typically achieves a high yield, with selectivity towards the desired impurity isomer. The reaction is performed under mild conditions to ensure the formation of the correct isomer.

About

CAS No 6202-23-9
English Name Nortriptyline EP Impurity E HCl (Amitriptyline EP Impurity B HCl)
Molecular Formula C20H22ClN
Molecular Weight 311.86 g/mol
SMILES CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31.Cl
InChIKey VXEAYBOGHINOKW-UHFFFAOYSA-N
Last Updated: 2025-09-26 00:09

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