2-Chloro-5-nitrophenol

Basic Information

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CAS Number

619-10-3

Molecular Formula

C6H4ClNO3

Molecular Weight

173.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

112°C

Boiling Point

276.1℃ at 760 mmHg

Density

1.554

Flash Point

120.8℃

Refractive Index

1.626

SMILES

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C1=CC(=C(C=C1[N+](=O)[O-])O)Cl

InChI

InChI=1S/C6H4ClNO3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H

InChIKey

BUMGQSCPTLELLS-UHFFFAOYSA-N

LogP

2.47700

Complexity

158

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

Z57160128
EN300-49224
C2077
6-Chloro-3-nitrophenol
2-chloro-5-nitro phenol
BUMGQSCPTLELLS-UHFFFAOYSA-
NSC-212119
DTXSID60210921
2-Chloro-5-nitrophenol
MFCD01571825
NS00034841
BUMGQSCPTLELLS-UHFFFAOYSA-N
EINECS 210-579-3
NSC 212119
CS-W021663
AMY18244
SY003235
2-chloro-5-nitro-phenol
InChI=1/C6H4ClNO3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H
Q-100714
O10742
619-10-3
NSC212119
AKOS005157673
5-nitro-2-chlorophenol
PS-6294
SCHEMBL343604
AKOS025395583
FT-0602490
AC-2883
Phenol, 2-chloro-5-nitro-

MDL Number

MFCD01571825

Customs Code

2908999090

FAQ

What are the physical and chemical properties of 2-Chloro-5-nitrophenol (CAS: 619-10-3)?

2-Chloro-5-nitrophenol (CAS: 619-10-3) is a crystalline solid with a molecular weight of approximately 184.57 g/mol. It is slightly soluble in water but soluble in most organic solvents. Chemically, it is highly reactive due to the presence of both a nitro and a chlorine substituent. It decomposes upon heating and reacts with bases to form chloroanilines and nitroanilines.

How is 2-Chloro-5-nitrophenol (CAS: 619-10-3) typically synthesized?

2-Chloro-5-nitrophenol can be synthesized via the nitration of 2-chlorophenol. The nitration is usually carried out using concentrated nitric acid and sulfuric acid as the nitrating agent. The reaction is typically performed under reflux conditions, and the product is purified by recrystallization from a suitable solvent.

What industries use 2-Chloro-5-nitrophenol (CAS: 619-10-3)?

2-Chloro-5-nitrophenol (CAS: 619-10-3) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring aromatic nitro and chloro functionalities. It is also used in the production of dyes, as an intermediate in polymer synthesis, and in the development of sensors and semiconductors.

What precautions should be taken when handling 2-Chloro-5-nitrophenol (CAS: 619-10-3)?

When handling 2-Chloro-5-nitrophenol (CAS: 619-10-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood. Spills should be cleaned up using appropriate materials, and the area should be well-ventilated. The material safety data sheet (MSDS) should be consulted for detailed safety instructions.