2-Chloro-5-nitrophenol(CAS: 619-10-3)

2-Chloro-5-nitrophenol (CAS: 619-10-3) is a crystalline solid with a molecular weight of approximately 184.57 g/mol. It is slightly soluble in water but soluble in most organic solvents. Chemically, it is highly reactive due to the presence of both a nitro and a chlorine substituent. It decomposes upon heating and reacts with bases to form chloroanilines and nitroanilines.

2-Chloro-5-nitrophenol can be synthesized via the nitration of 2-chlorophenol. The nitration is usually carried out using concentrated nitric acid and sulfuric acid as the nitrating agent. The reaction is typically performed under reflux conditions, and the product is purified by recrystallization from a suitable solvent.

2-Chloro-5-nitrophenol (CAS: 619-10-3) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring aromatic nitro and chloro functionalities. It is also used in the production of dyes, as an intermediate in polymer synthesis, and in the development of sensors and semiconductors.

When handling 2-Chloro-5-nitrophenol (CAS: 619-10-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood. Spills should be cleaned up using appropriate materials, and the area should be well-ventilated. The material safety data sheet (MSDS) should be consulted for detailed safety instructions.