Z-Gly-gln-OH | CAS No. 6154-39-8

Z-Gly-gln-OH

Basic Information

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CAS Number

6154-39-8

Molecular Formula

C15H19N3O6

Molecular Weight

337.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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C1=CC=C(C=C1)COC(=O)NCC(=O)NC(CCC(=O)N)C(=O)O

InChI

InChI=1S/C15H19N3O6/c16-12(19)7-6-11(14(21)22)18-13(20)8-17-15(23)24-9-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H2,16,19)(H,17,23)(H,18,20)(H,21,22)/t11-/m0/s1

InChIKey

BYMPQNRKDGXXFG-NSHDSACASA-N

LogP

-0.25229999999999875

Topological Polar Surface Area

147.82000000000002 Å²

Hydrogen Bond Donor/Acceptor

5 / 9

Complexity

462

Synonyms & References

English

z-gly-gln-oh
Cbz-Gly-L-Gln
Z-Gly-Glu(NH2)OH
SCHEMBL9319378
6154-39-8
((Benzyloxy)carbonyl)glycyl-L-glutamine
CS-0454217
(S)-5-amino-2-(2-(benzyloxycarbonylamino)acetamido)-5-oxopentanoic acid
MFCD00238447
(2S)-5-amino-5-oxo-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]pentanoic acid
Z-GLY-GLN-OH

MDL Number

MFCD00238447

FAQ

What are the physical and chemical properties of Z-Gly-gln-OH (CAS: 6154-39-8)?

Z-Gly-gln-OH (CAS: 6154-39-8) is a crystalline compound with a molecular weight of approximately 268.3 g/mol. It is soluble in water and has a pKa of around 9.5, indicating it is a weak base. The compound is mildly reactive, particularly in acidic conditions. It is stable under normal storage conditions but should be protected from strong acids and bases.

How is Z-Gly-gln-OH (CAS: 6154-39-8) typically synthesized?

Z-Gly-gln-OH (CAS: 6154-39-8) can be synthesized via solid-phase peptide synthesis methods. The key steps involve coupling glycine (Gly) and glutamine (Gln) amino acids using appropriate coupling reagents and protecting groups. The coupling is typically carried out in an organic solvent such as dichloromethane (DCM) and catalyzed by a carbodiimide like N,N'-dicyclohexylcarbodiimide (DCC). The final step involves deprotection and cleavage from the resin support.

What industries use Z-Gly-gln-OH (CAS: 6154-39-8)?

Z-Gly-gln-OH (CAS: 6154-39-8) is primarily used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also utilized in the polymer industry for modifying polymer properties, and in the sensor industry for developing biosensors. Additionally, it has applications in the semiconductor industry for thin film deposition.

What precautions should be taken when handling Z-Gly-gln-OH (CAS: 6154-39-8)?

When handling Z-Gly-gln-OH (CAS: 6154-39-8), proper personal protective equipment (PPE) should be worn, including gloves and safety glasses. It should be stored in a cool, dry place away from strong acids and bases. In case of a spill, it should be cleaned up using appropriate absorbent materials. For detailed safety information, refer to the Safety Data Sheet (SDS).