Z-Gly-gln-OH(CAS: 6154-39-8)

Z-Gly-gln-OH (CAS: 6154-39-8) is a crystalline compound with a molecular weight of approximately 268.3 g/mol. It is soluble in water and has a pKa of around 9.5, indicating it is a weak base. The compound is mildly reactive, particularly in acidic conditions. It is stable under normal storage conditions but should be protected from strong acids and bases.

Z-Gly-gln-OH (CAS: 6154-39-8) can be synthesized via solid-phase peptide synthesis methods. The key steps involve coupling glycine (Gly) and glutamine (Gln) amino acids using appropriate coupling reagents and protecting groups. The coupling is typically carried out in an organic solvent such as dichloromethane (DCM) and catalyzed by a carbodiimide like N,N'-dicyclohexylcarbodiimide (DCC). The final step involves deprotection and cleavage from the resin support.

Z-Gly-gln-OH (CAS: 6154-39-8) is primarily used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also utilized in the polymer industry for modifying polymer properties, and in the sensor industry for developing biosensors. Additionally, it has applications in the semiconductor industry for thin film deposition.

When handling Z-Gly-gln-OH (CAS: 6154-39-8), proper personal protective equipment (PPE) should be worn, including gloves and safety glasses. It should be stored in a cool, dry place away from strong acids and bases. In case of a spill, it should be cleaned up using appropriate absorbent materials. For detailed safety information, refer to the Safety Data Sheet (SDS).