3-(1-Piperazinyl)phenol

Basic Information

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CAS Number

59817-32-2

Molecular Formula

C10H14N2O

Molecular Weight

178.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

217-221 °C

Boiling Point

371.3°C at 760 mmHg

Density

1.141

Flash Point

178.3°C

Refractive Index

1.576

SMILES

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C1CN(CCN1)C2=CC(=CC=C2)O

InChI

InChI=1S/C10H14N2O/c13-10-3-1-2-9(8-10)12-6-4-11-5-7-12/h1-3,8,11,13H,4-7H2

InChIKey

AYGYICRITMSJOC-UHFFFAOYSA-N

LogP

0.8017999999999996

Topological Polar Surface Area

35.5 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

157

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

59817-32-2
SY062274
1-(3-Hydroxyphenyl)piperazine
Oprea1_613831
AKOS001393913
3-(1-Piperazino)phenol
EN300-21779
n-(3-hydroxyphenyl)piperazine
DTXSID00371469
1-(3-Hydroxyphenyl) piperazine
3-(1-piperazinyl)phenol
1-(3-HYDROXYPHENYL)-PIPERAZINE
FS-1233
FT-0629178
CS-0106190
A832481
Z118507070
MFCD00052896
3-piperazin-1-ylphenol
AYGYICRITMSJOC-UHFFFAOYSA-N
1-(3-Hydroxyphenyl) piperazine, 97%
Phenol, 3-(1-piperazinyl)-
3-hydroxyphenyl piperazine
3-piperazin-1-yl-phenol
3-piperazine-1-yl-phenol
3-hydroxyphenylpiperazine
3-(piperazin-1-yl)phenol
SCHEMBL788160
1-(3-HYDROXYPHENYL)PIPERAZINE
3-(Piperazin-1-yl)phenol

MDL Number

MFCD00052896

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 3-(1-Piperazinyl)phenol (CAS: 59817-32-2)?

3-(1-Piperazinyl)phenol is a crystalline solid with a molecular weight of approximately 203.24 g/mol. It has a pKa value around 9.3, indicating basic properties. Soluble in water and organic solvents, it reacts with acids to form salts and can act as a nucleophile in substitution reactions.

How is 3-(1-Piperazinyl)phenol (CAS: 59817-32-2) typically synthesized?

3-(1-Piperazinyl)phenol can be synthesized via the reaction of p-phenol with 1-piperazinecarboxylic acid. This typically involves a condensation reaction followed by acid workup to yield the product with good selectivity and moderate yield. A suitable catalyst, such as a Lewis acid, may be used to enhance reactivity.

What industries use 3-(1-Piperazinyl)phenol (CAS: 59817-32-2)?

3-(1-Piperazinyl)phenol is used in pharmaceuticals as a precursor for drugs, in polymers for specific properties enhancement, in sensors for chemical detection, and in semiconductors for etching processes.

What precautions should be taken when handling 3-(1-Piperazinyl)phenol (CAS: 59817-32-2)?

Proper handling of 3-(1-Piperazinyl)phenol requires the use of personal protective equipment such as safety goggles and gloves. It should be stored in a cool, dry place, away from strong oxidizers. In case of spill, use appropriate absorbents and dispose of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.