3-(1-Piperazinyl)phenol(CAS: 59817-32-2)

3-(1-Piperazinyl)phenol is a crystalline solid with a molecular weight of approximately 203.24 g/mol. It has a pKa value around 9.3, indicating basic properties. Soluble in water and organic solvents, it reacts with acids to form salts and can act as a nucleophile in substitution reactions.

3-(1-Piperazinyl)phenol can be synthesized via the reaction of p-phenol with 1-piperazinecarboxylic acid. This typically involves a condensation reaction followed by acid workup to yield the product with good selectivity and moderate yield. A suitable catalyst, such as a Lewis acid, may be used to enhance reactivity.

3-(1-Piperazinyl)phenol is used in pharmaceuticals as a precursor for drugs, in polymers for specific properties enhancement, in sensors for chemical detection, and in semiconductors for etching processes.

Proper handling of 3-(1-Piperazinyl)phenol requires the use of personal protective equipment such as safety goggles and gloves. It should be stored in a cool, dry place, away from strong oxidizers. In case of spill, use appropriate absorbents and dispose of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.