Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine

Basic Information

View in Editor

CAS Number

56001-37-7

Molecular Formula

C10H14N5Na2O14P3

Molecular Weight

567.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

180°C

Boiling Point

1028.3°Cat760mmHg

Water Solubility

Soluble in water.

Flash Point

575.7°C

SMILES

View in Editor

C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)O)O)O)N=C(NC2=O)N.[Na+].[Na+]

InChI

InChI=1S/C10H16N5O14P3.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1

InChIKey

FIZIYLKEXVIRHJ-LGVAUZIVSA-L

LogP

-0.87810

Complexity

910

Safety Information

View Safety Information

GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

对热敏感

Synonyms & References

English

MFCD00083629
disodium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphono phosphate
SCHEMBL20578211
56001-37-7
Guanosine 5'-triphosphate disodium salt
Guanosine-5'-triphosphoric aicd disodium salt
5'-GTP disodium salt
Guanosine-5-triphosphate disodium salt
GUANOSINE-5'-TRIPHOSPHATE DISODIUM SALT
Guanosine-5/'-triphosphoric aicd disodium salt
disodium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphono phosphate
guanosine 5'-(disodium dihydrogen triphosphate)
Guanosine-5'-triphosphate disodium salt
GTP, NA2H2
Guanosine 5′-Triphosphate, Disodium Salt
GTP
GTP.Na2
GUANOSINE TRIPHOSPHATE
Guanosine-5'-triphosphate
guanosine 5'-triphosphate
Guanosine 5'-(tetrahydrogen triphosphate)
5'-GTP
Guanosine 5'-triphosphoric acid
H4gtp
01WV7J708X
guanosintriphosphat
1jlr
guanosine-5'-(tetrahydrogentriphosphate)
1j2j
Guanosine 5_-triphosphate
[3h]guanosine triphosphate

MDL Number

MFCD00083629

FAQ

What are the physical and chemical properties of Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7)?

Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7) is a phosphonate ester derivative of guanosine. It crystallizes in a stable form with a high melting point. The molecular weight is approximately 942.16 g/mol. It has poor water solubility and exhibits low reactivity under normal conditions. This compound is stable under acidic and basic conditions but susceptible to hydrolysis in the presence of moisture.

How is Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7) typically synthesized?

Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7) is synthesized using a multi-step process involving the condensation of guanosine with a phosphonate, followed by a series of phosphonate esterification reactions. Commonly used catalysts include titanium(IV) isopropoxide and other organometallic compounds. The reaction yields around 85% of the desired product. The process is carried out in a controlled environment to ensure high purity and yield.

What industries use Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7)?

Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7) is primarily used in the pharmaceutical industry for the development of novel nucleoside analogs with potential antiviral and anticancer properties. It is also explored in the field of molecular biology for studying nucleic acid structures and functions. Additionally, it has applications in the sensor industry for detecting specific nucleic acids and in the semiconductor industry for electronic applications.

What precautions should be taken when handling Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7)?

When handling Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine (CAS: 56001-37-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place, away from direct sunlight and heat sources. In case of spills, they should be immediately cleaned up with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.