2-Nitrobenzenesulfonamide

Basic Information

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CAS Number

5455-59-4

Molecular Formula

C6H6N2O4S

Molecular Weight

202.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

192.0 to 196.0 deg-C

Boiling Point

418.8℃ at 760 mmHg

Water Solubility

Slightly soluble in water.

Flash Point

207.1°C

Refractive Index

1.6490 (estimate)

SMILES

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C1=CC=C(C(=C1)[N+](=O)[O-])S(=O)(=O)N

InChI

InChI=1S/C6H6N2O4S/c7-13(11,12)6-4-2-1-3-5(6)8(9)10/h1-4H,(H2,7,11,12)

InChIKey

GNDKYAWHEKZHPJ-UHFFFAOYSA-N

LogP

2.54650

Complexity

289

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-nitrobenzene-1-sulfonamide
NSC629275
MFCD00009807
2-NITROPHENYL SULFONYLAMINE
EN300-15720
CHEMBL361396
NSC 23381
AKOS000200557
A830240
NSC-23381
AB01099064-03
NCGC00338999-01
BP-12501
2-Nitrobenzenesulfonamide
2-(Hydroxy(oxido)amino)benzenesulfonamide
2-Nitrobenzenesulfonamide, 98%
AMY5016
CS-W008096
Z45415562
NSC-629275
FT-0613180
5455-59-4
BCP25648
HY-W008096
SY058096
1-nitro-2-(sulfinatoamino)benzene
PS-6117
J-510172
DTXSID30202974
SB37611
SCHEMBL370668

MDL Number

MFCD00009807

Customs Code

2935009090

FAQ

What are the physical and chemical properties of 2-Nitrobenzenesulfonamide (CAS: 5455-59-4)?

2-Nitrobenzenesulfonamide (CAS: 5455-59-4) is a white crystalline solid with a molecular weight of 217.09 g/mol. It has a melting point of 155-157°C and is slightly soluble in water. It exhibits good solubility in common organic solvents like methanol, ethanol, and acetone. This compound is chemically stable but can react with strong bases to form 2-amino-5-nitrobenzenesulfonate. It is used as a reagent in organic synthesis and pharmaceutical industry.

How is 2-Nitrobenzenesulfonamide (CAS: 5455-59-4) typically synthesized?

2-Nitrobenzenesulfonamide (CAS: 5455-59-4) is usually synthesized by the reaction of 2-nitrobenzenesulfonyl chloride with ammonia in the presence of a catalyst such as sodium hydroxide. This process involves the nucleophilic attack of ammonia on the sulfonyl chloride group, followed by work-up to obtain the desired amide. The yield and selectivity are typically very good, with high purity products being obtained.

What industries use 2-Nitrobenzenesulfonamide (CAS: 5455-59-4)?

2-Nitrobenzenesulfonamide (CAS: 5455-59-4) is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It is also used in the polymer industry for the preparation of functionalized polymers. Additionally, it has applications in the sensor industry for the development of chemical sensors and in the semiconductor industry as a dopant.

What precautions should be taken when handling 2-Nitrobenzenesulfonamide (CAS: 5455-59-4)?

When handling 2-Nitrobenzenesulfonamide (CAS: 5455-59-4), it is essential to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be carefully contained and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.