5-Chloro-8-quinolinamine

Basic Information

View in Editor

CAS Number

5432-09-7

Molecular Formula

C9H7ClN2

Molecular Weight

178.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

C1=CC2=C(C=CC(=C2N=C1)N)Cl

InChI

InChI=1S/C9H7ClN2/c10-7-3-4-8(11)9-6(7)2-1-5-12-9/h1-5H,11H2

InChIKey

TVSJIVLFKNZFBJ-UHFFFAOYSA-N

LogP

2.4704000000000006

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

163

Synonyms & References

English

TVSJIVLFKNZFBJ-UHFFFAOYSA-N
EN300-28776
SCHEMBL2423195
5-Chloro-8-quinolinamine
5432-09-7
DTXSID60279679
CS-0453427
(5-Chloro-8-quinolyl)amine
8-Quinolinamine, 5-chloro-
MB01218
NSC-13700
AKOS001428539
AMY25157
NSC13700
FT-0714391
Z235362213
MFCD00461243
AS-43466
5-chloro-8-aminoquinoline
5-chloroquinolin-8-amine
m-phthaldialdehyde
5-Chloro-8-aminoquinoline
8-Amino-5-chloroquinoline
m-phthaldialdehyd
(5-chloro-8-quinolyl)amine
5-Chloro-8-quinolylamine
5-CHLOROQUINOLIN-8-AMINE
8-Quinolinamine,5-chloro-
5-Chlor-[8]chinolylamin
5-Chloro-8-aminochinolin
8-amino-5-chloro-quinoline

MDL Number

MFCD00461243

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 5-Chloro-8-quinolinamine (CAS: 5432-09-7)?

5-Chloro-8-quinolinamine is a white crystalline solid with a molecular weight of approximately 221.58 g/mol. It has a solubility of about 80 mg/L in water and is moderately soluble in organic solvents. Chemically, it is a weak base, and it can undergo nucleophilic substitution reactions and condensation reactions.

How is 5-Chloro-8-quinolinamine (CAS: 5432-09-7) typically synthesized?

5-Chloro-8-quinolinamine can be synthesized by the condensation of 8-hydroxyquinoline with thionyl chloride followed by hydrolysis. The key steps involve the formation of an intermediate chloro compound and subsequent hydrolysis to form the amine. This process is carried out under basic conditions with good yield and selectivity.

What industries use 5-Chloro-8-quinolinamine (CAS: 5432-09-7)?

5-Chloro-8-quinolinamine is primarily used in the pharmaceutical industry for the synthesis of certain drug candidates. It is also used in the development of sensors and as a precursor in the production of functional materials for semiconductors and organic polymers.

What precautions should be taken when handling 5-Chloro-8-quinolinamine (CAS: 5432-09-7)?

Proper handling of 5-Chloro-8-quinolinamine requires the use of appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of spill, it should be handled in a fume hood with appropriate cleanup procedures following the safety data sheet (SDS).