5-Chloro-8-quinolinamine(CAS: 5432-09-7)

5-Chloro-8-quinolinamine is a white crystalline solid with a molecular weight of approximately 221.58 g/mol. It has a solubility of about 80 mg/L in water and is moderately soluble in organic solvents. Chemically, it is a weak base, and it can undergo nucleophilic substitution reactions and condensation reactions.

5-Chloro-8-quinolinamine can be synthesized by the condensation of 8-hydroxyquinoline with thionyl chloride followed by hydrolysis. The key steps involve the formation of an intermediate chloro compound and subsequent hydrolysis to form the amine. This process is carried out under basic conditions with good yield and selectivity.

5-Chloro-8-quinolinamine is primarily used in the pharmaceutical industry for the synthesis of certain drug candidates. It is also used in the development of sensors and as a precursor in the production of functional materials for semiconductors and organic polymers.

Proper handling of 5-Chloro-8-quinolinamine requires the use of appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of spill, it should be handled in a fume hood with appropriate cleanup procedures following the safety data sheet (SDS).