5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one | CAS No. 53786-28-0
5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one
Basic Information
CAS Number
53786-28-0
Molecular Formula
C12H14ClN3O
Molecular Weight
251.72 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
226.0 to 230.0 deg-C
Density
1.3±0.1 g/cm3
Refractive Index
1.605
Safety Information
View Safety InformationHazard Statement
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
Synonyms & References
English
- 5-chloro-1-(4-piperidyl)- 2-benzimidazolinone
- SCHEMBL22588043
- Tox21_113838
- 5-CHLORO-1-(4-PIPERIDINYL)-2-BENZIMIDAZOLIDINONE
- DOMPERIDONE IMPURITY A
- 5-Chloro-1-(4-piperidyl)-1H-benzimidazol-2(3H)-one
- SR-01000945186-1
- SR-01000945186
- 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2h-benzimidazol-2-one
- DTXSID4057764
- Domperidone Imp. A (EP); 5-Chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one; Domperidone Impurity A
- CHEMBL3189082
- 5-CHLORO-1-PIPERIDIN-4-YL-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE
- AB10845
- 1-(4-piperidyl)-5-chloro-benzimidazolin-2-one
- 1-(4-Piperidinyl)-1,3-dihydro-5-chlorobenzimidazolone
- 5-Chloro-1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one
- 4-(5-Chlorobenzimidazol-2-on-1-yl)-piperidine
- R29676
- 5-Chloro 1,3 dihydro -1- (4-piperidinyl) -2H- benzimidazol - 2 -one
- 4-(6-CHLORO-1,2-DIHYDRO-2-OXOBENZO(D)IMIDAZOL-3-YL)PIPERIDINE
- 5-Chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
- FT-0640191
- PD065624
- 5-CHLORO-1,3-DIHYDRO-1-(PIPERIDIN-4-YL)-2H-BENZIMIDAZOL-2-ONE
- DoMperidone EP IMpurity A
- DOAYWDKFDPSTSV-UHFFFAOYSA-N
- SCHEMBL655853
- BCP34405
- 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one
- 5-Chloro-1-(4-piperidinyl)-2-benzimidazolinone
MDL Number
MFCD02684518
Customs Code
2933990090
FAQ
What are the physical and chemical properties of 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 53786-28-0)?
5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one is a solid with a crystalline form. It has a molecular weight of approximately 253.67 g/mol and is slightly soluble in water. It shows limited reactivity under normal conditions but can degrade under strong acidic or basic conditions. The compound can be effectively dissolved in organic solvents such as ethanol and acetone.
How is 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 53786-28-0) typically synthesized?
This compound is typically synthesized via the condensation of 5-chlorobenzimidazole with 4-piperidinecarboxylic acid, followed by a coupling reaction using a suitable coupling reagent like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction requires basic conditions and is conducted with good selectivity and yield, often over 90%.
What industries use 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 53786-28-0)?
5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one finds applications in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It is also utilized in the polymer industry as a stabilizer and in the sensor industry for its ability to detect specific chemical species. Additionally, it has applications in semiconductor manufacturing as a photoresist component.
What precautions should be taken when handling 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 53786-28-0)?
When handling 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, it is recommended to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area away from heat sources and direct sunlight. In case of spill, the area should be flushed with water, and the spill should be cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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