5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one(CAS: 53786-28-0)

5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one is a solid with a crystalline form. It has a molecular weight of approximately 253.67 g/mol and is slightly soluble in water. It shows limited reactivity under normal conditions but can degrade under strong acidic or basic conditions. The compound can be effectively dissolved in organic solvents such as ethanol and acetone.

This compound is typically synthesized via the condensation of 5-chlorobenzimidazole with 4-piperidinecarboxylic acid, followed by a coupling reaction using a suitable coupling reagent like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction requires basic conditions and is conducted with good selectivity and yield, often over 90%.

5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one finds applications in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It is also utilized in the polymer industry as a stabilizer and in the sensor industry for its ability to detect specific chemical species. Additionally, it has applications in semiconductor manufacturing as a photoresist component.

When handling 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, it is recommended to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area away from heat sources and direct sunlight. In case of spill, the area should be flushed with water, and the spill should be cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.